Shanghai Journal of Stomatology

Shanghai Journal of Stomatology ›› 2014, Vol. 23 ›› Issue (3): 317-321.

• Clinical Study • Previous Articles     Next Articles

Expression and clinical significance of Cox-2 and XIAP in malignant tumors of the salivary gland

NING Zhao-rong1, LI Song2, GUO Yan-wei1, FANG Dian-ji3   

  1. 1.Department of Oral and Maxillofacial Surgery, Jiamusi University Hospital of Stomatology. Jiamusi 154002, Heilongjiang Province;
    2.Department of Oral and Maxillofacial Surgery, Changchun Hospital of Stomatology. Changchun 130000, Jilin Province;
    3.Department of Oral and Maxillofacial Surgery, The Fifth People’s Hospital of Fudan University. Shanghai 200240, China
  • Received:2013-07-31 Online:2014-06-20 Published:2014-09-09
  • Supported by:
    Supported by National Natural Science Foundation of China (81170935).

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Abstract: PURPOSE: To detect the expression of Cox-2 and XIAP in adenoid cystic carcinoma (ACC) and mucoepidermoid carcinoma (MEC) of salivary glands. To study the role and correlation between the expression of Cox-2 and XIAP in malignant tumors of salivary gland. METHODS: Immunohistochemical SP staining method was used to quantify the protein expression levels of Cox-2 and XIAP in 95 patients with malignant tumors of the salivary gland (50 ACCs,45 MECs),10 patients with pleomorphic adenoma and 10 persons with normal salivary gland tissues. SPSS17.0 software package was used to analyze the data. RESULTS: Cox-2 and XIAP were expressed strongly in malignant tumors of the salivary gland, while they not expressed in pleomorphic adenoma and normal salivary gland tissues. The expression of Cox-2 and XIAP in malignant tumors of salivary gland was correlated with clinical stage and lymphnode metastasis, while they not correlated with primary sites (P>0.05). CONCLUSIONS: The high expression of Cox-2 and XIAP in malignant tumors of salivary gland may play an important role in the development of malignant tumors of the salivary gland.

Key words: Cox-2, XIAP, Adenoid cystic carcinoma, Mucoepidermoid carcinoma

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