上海口腔医学

上海口腔医学 ›› 2025, Vol. 34 ›› Issue (5): 513-517.doi: 10.19439/j.sjos.2025.05.011

• 论著 • 上一篇    下一篇

SIRT1、SOCS6在重度慢性牙周炎患者牙龈组织中的表达及临床意义

杨绍威1, 盛健2, 费晨艳1, 蔡琪1   

  1. 1.嘉兴市第二医院 口腔科,2.科教科,浙江 嘉兴 314000
  • 收稿日期:2024-06-25 修回日期:2024-08-26 出版日期:2025-10-25 发布日期:2025-10-31
  • 通讯作者: 蔡琪,E-mail：byron1975@163.com
  • 作者简介:杨绍威（1988-）,男,硕士,E-mail：yyyy1602@163.com
  • 基金资助:
    浙江省医药卫生科技计划项目（2024KY1680）

Expression and clinical significance of SIRT1 and SOCS6 in gingival tissue of patients with severe chronic periodontitis

Yang Shaowei1, Sheng Jian2, Fei Chenyan1, Cai Qi1   

  1. 1. Department of Stomatology, 2. Department of Science and Education, Jiaxing Second Hospital. Jiaxing 314000, Zhejiang Province, China
  • Received:2024-06-25 Revised:2024-08-26 Online:2025-10-25 Published:2025-10-31

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摘要： 目的:探讨沉寂信息调节因子（silent information regulator 1,SIRT1）、细胞因子信号传导抑制因子6（cytokine signaling 6,SOCS6）在重度慢性牙周炎（chronic periodontitis,CP）患者牙龈组织中的表达及临床意义。方法:选择2022年4月—2024年4月在嘉兴市第二医院就诊的CP患者213例,根据病情严重程度分为轻度组（n=35）、中度组（n=91）和重度组（n=87）;另选取同期95例进行牙冠延长术的健康牙周患者作为对照组。采用qRT-PCR法检测牙龈组织中SIRT1、SOCS6 mRNA表达水平,多因素logistic回归分析影响重度CP发生的相关因素,受试者工作特征（ROC）曲线分析牙龈组织中SIRT1、SOCS6表达水平对重度CP的诊断效能。结果:重度组白细胞介素10（IL-10）、C反应蛋白（CRP）、白细胞介素17（IL-17）水平显著高于轻、中度组（P<0.05）。重度组牙龈组织中SIRT1、SOCS6表达水平显著低于轻、中度组和对照组,轻、中度组牙龈组织中SIRT1、SOCS6表达水平显著低于对照组（P<0.05）。牙龈组织中SIRT1、SOCS6、IL-10、IL-17为影响重度CP发生的相关因素（P<0.05）。牙龈组织中SIRT1、SOCS6及两者联合诊断重度CP的曲线下面积（area under the curve,AUC）分别为0.833、0.825、0.896,优于单一指标诊断（P<0.05）,联合诊断的敏感度和特异度分别为91.95%和78.57%。结论:重度CP患者牙龈组织中SIRT1、SOCS6表达水平显著降低,是重度CP发生的相关因素,两者联合检测对重度CP的发生有较高的诊断效能。

关键词: 重度慢性牙周炎, 沉寂信息调节因子, 细胞因子信号传导抑制因子6, 诊断效能

Abstract: PURPOSE: To investigate the expression and clinical significance of silent information regulator 1 (SIRT1) and suppressor of cytokine signaling 6(SOCS6) in gingival tissue of patients with severe chronic periodontitis (CP). METHODS: A total of 213 CP patients treated in Jiaxing Second Hospital from April 2022 to April 2024 were selected and divided into mild group (n=35), moderate group (n=91) and severe group (n=87) according to the severity of the disease. Another 95 patients with healthy periodontium who underwent crown lengthening were selected as control group. qRT-PCR was used to detect SIRT1 and SOCS6 mRNA expression levels in gingival tissues. Multivariate logistic regression was used to analyze the related factors affecting the occurrence of severe CP. Receiver operating characteristic(ROC) curve was used to analyze the diagnostic efficacy of SIRT1 and SOCS6 expression levels in gingival tissues for severe CP. RESULTS: The levels of interleukin-10 (IL-10), C-reactive protein (CRP), and interleukin-17(IL-17) in the severe group were significantly higher than those in the moderate to mild group(P<0.05). The expression levels of SIRT1 and SOCS6 in the gingival tissue of the severe group were significantly lower than those of the moderate to mild group and the control group, the expression levels of SIRT1 and SOCS6 in the gingival tissue of the moderate to mild group were significantly lower than those of the control group (P<0.05). SIRT1, SOCS6, IL-10, and IL-17 in gingival tissue were related factors affecting the occurrence of severe CP (P<0.05). The area under the curve (AUC) of SIRT1, SOCS6, and their combination in the diagnosis of severe CP was 0.833, 0.825, and 0.896, respectively, which was superior to single indicator for diagnosis(P<0.05). The sensitivity and specificity of the combined diagnosis were 91.95% and 78.57%, respectively. CONCLUSIONS: The expression levels of SIRT1 and SOCS6 in gingival tissue of patients with severe CP are greatly reduced, which are related factors for severe CP. Detection of SIRT1 and SOCS6 has high diagnostic efficacy for severe CP.

Key words: Severe chronic periodontitis, Silent information regulator 1, Suppressor of cytokine signaling 6, Diagnostic efficiency

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