上海口腔医学

上海口腔医学 ›› 2024, Vol. 33 ›› Issue (5): 449-454.doi: 10.19439/j.sjos.2024.05.001

• 论著 • 上一篇    下一篇

n-HA/壳聚糖/米诺环素复合支架在种植体周围炎骨缺损模型中的应用效果评价

牛婉琼1,2, 汪振华2, 周志伟2   

  1. 1.石河子大学医学院, 新疆 石河子 832099;
    2.乌鲁木齐市口腔医院 修复科, 新疆 乌鲁木齐 830002
  • 收稿日期:2024-05-28 修回日期:2024-07-01 出版日期:2024-10-25 发布日期:2024-11-14
  • 通讯作者: 汪振华,E-mail: 670952885@qq.com
  • 作者简介:牛婉琼（1994-）,女,汉族,硕士研究生,主治医师,E-mail: 1418327243@qq.com
  • 基金资助:
    新疆维吾尔自治区自然科学基金（2020D01A28）

Application and evaluation of n-HA/ chitosan/minocycline composite scaffold in the model of peri-implant inflammatory bone defect

NIU Wan-qiong1,2, WANG Zhen-hua2, ZHOU Zhi-wei2   

  1. 1. Shihezi University School of Medicine. Shihezi 832099;
    2. Department of Prosthodontics, Urumqi Stomatological Hospital. Urumqi 830002, Xinjiang Uygur Autonomous Region, China
  • Received:2024-05-28 Revised:2024-07-01 Online:2024-10-25 Published:2024-11-14

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摘要： 目的： 评价n-HA/壳聚糖/米诺环素复合支架在种植体周围炎骨缺损模型中的应用效果。方法： 选择健康成年雄性实验用比格犬12只,构建种植体周围炎骨缺损模型。对照组（6只）在骨缺损区域内不做任何处理,由牙槽窝自愈方式进行骨再生;实验组（6只）将制备的n-HA/壳聚糖/米诺环素复合支架植入骨缺损部位。记录2组动物模型牙周炎、骨缺损、病理学指标、骨密度（bone mineral density）和新骨形成率。采用SPSS 26.0软件包对数据进行统计学分析。结果： 对照组和实验组术前骨缺损水平宽度与垂直深度相比无显著差异（P>0.05）。术后4周、8周、12周时,实验组骨缺损水平宽度、垂直深度显著低于术前和对照组（P<0.05）。对照组和实验组术前牙周探诊深度（probing depth,PD）、龈沟出血指数（sulcus bleeding index,SBI）和菌斑指数（plaque index,PLI）相比无显著差异（P>0.05）。术后4周、8周、12周时,实验组PD、SBI和PLI显著高于术前和对照组（P<0.05）。术后4周、8周、12周时,实验组BMD值、新生骨高度和新骨形成率显著高于对照组（P<0.05）。结论： n-HA/壳聚糖/米诺环素复合支架用于种植体周围炎骨缺损模型效果较好,可促进种植体周围骨缺损区域的骨结合与骨再生。

关键词: 种植体周围炎, 骨缺损, 米诺环素, 纳米羟基磷灰石, 壳聚糖

Abstract: PURPOSE: To analyze the effect of n-HA/chitosan/minocycline composite scaffold in the animal model of peri-implant inflammatory bone defect. METHODS: Twelve healthy adult male beagle dogs were selected to construct the model of peri-implant inflammatory bone defect. The control group(n=6) underwent bone regeneration by alveolar self-healing without any treatment in the bone defect area. In the experimental group(n=6), n-HA/chitosan/minocycline composite scaffold prepared was implanted into the bone defect site. Periodontitis, bone defect, pathological parameters, bone mineral density(BMD) and new bone formation rate were recorded in two groups of animal models. Statistical analysis was performed with SPSS 26.0 software package. RESULTS: There was no significant difference in the horizontal width and vertical depth of bone defect between the control group and the experimental group before treatment (P>0.05). At 4, 8 and 12 weeks after treatment, the horizontal width and vertical depth of the experimental group were significantly lower than those before treatment and the control group(P<0.05). There was no significant difference in probing depth(PD), sulcus bleeding index(SBI) and plaque index(PLI) between the control group and the experimental group before treatment(P>0.05). PD, SBI and PLI in the experimental group were significantly higher than those before treatment and in the control group at 4, 8 and 12 weeks after treatment(P<0.05). BMD value, new bone height and new bone formation rate of the experimental group were significantly higher than those of the control group at 4, 8 and 12 weeks after treatment(P<0.05). CONCLUSIONS: n-HA/chitosan/minocycline composite scaffold shows a good effect in the model of peri-implant inflammatory bone defect, which can promote bone osteointegration and bone regeneration in the peri-implant bone defect area.

Key words: Perimplantitis, Bone defect, Minocycline, Nano-hydroxyapatite, Chitosan

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