口服右旋酮洛芬氨丁三醇在阻生牙拔除术中的超前镇痛：随机对照双盲试验

doi:10.19439/j.sjos.2023.03.015

上海口腔医学 ›› 2023, Vol. 32 ›› Issue (3): 298-301.doi: 10.19439/j.sjos.2023.03.015

口服右旋酮洛芬氨丁三醇在阻生牙拔除术中的超前镇痛：随机对照双盲试验

赵君^1,2,3, 吴晓波^2,3, 刘娜⁴, 周瑜⁵, 郝新河^1,2,3

1.合肥市口腔医院口腔颌面外科,安徽合肥 230001;
2.安徽医科大学合肥口腔临床学院,安徽合肥 230001;
3.安徽医科大学第五临床医学院,安徽合肥 230022;
4.安徽医科大学第一附属医院口腔科,安徽合肥 230022;
5.中国科学技术大学附属第一医院口腔科,安徽合肥 230001

收稿日期:2022-12-22 修回日期:2023-02-09 出版日期:2023-06-25 发布日期:2023-06-28
通讯作者: 刘娜,E-mail:hxnana@foxmail.com
作者简介:赵君(1981-),男,博士,副主任医师,E-mail:ykzj1981@126.com
基金资助:
2022年安徽医科大学校级科研基金（2022xkj257）

Oral dexketoprofen tromethamine for preemptive analgesia in extraction of impacted teeth: a randomized controlled double-blind trial

ZHAO Jun^1,2,3, WU Xiao-bo^2,3, LIU Na⁴, ZHOU Yu⁵, HAO Xin-he^1,2,3

1. Department of Oral and Maxillofacial Surgery, Hefei Stomatology Hospital. Hefei 230001;
2. Hefei Clinical School of Stomatology, Anhui Medical University. Hefei 230001;
3. The Fifth Clinical College of Medicine, Anhui Medical University. Hefei 230022;
4. Department of Oral Medicine, The First Affiliated Hospital of Anhui Medical University. Hefei 230022;
5. Department of Oral Medicine, The First Affiliated Hospital of University of Science and Technology of China. Hefei 230001, Anhui Province, China

Received:2022-12-22 Revised:2023-02-09 Online:2023-06-25 Published:2023-06-28

摘要/Abstract

摘要： 目的：研究右旋酮洛芬氨丁三醇在阻生牙拔除术中的超前镇痛作用。方法：选取拔除双侧下颌阻生牙的患者20例,通过随机自身对照原则,将两侧阻生牙分为右旋酮洛芬氨丁三醇组（试验组）与安慰剂组（对照组）。通过数值评定量表(numeric rating scale,NRS)统计患者在拔牙术后0.5、2、4、8、12、24 h疼痛评分,记录24 h内使用应急镇痛药物的总剂量,COX分析法比较患者2次术后首次应用应急镇痛药物的间隔时间及例数,绘制生存曲线。采用SPSS 20.0软件包对数据进行统计学分析。结果：手术后2、4、8、12 h,试验组患者术后疼痛的NRS评分显著低于对照组（P<0.05）,24 h试验组使用应急镇痛药物剂量显著低于对照组（P<0.05）。生存曲线表明,试验组首次应用镇痛药物的间隔时间显著长于对照组（P<0.05）。结论：右旋酮洛芬氨丁三醇用于阻生牙拔除术的超前镇痛时,12 h内可取得明显的止疼作用,但12小时后镇痛效果不明显。

关键词: 右旋酮洛芬氨丁三醇, 阻生牙拔除, 超前镇痛, 数值评定量表

Abstract: PURPOSE: To study the preemptive analgesic effect of dexketoprofen tromethamine in extraction of impacted teeth. METHODS: Twenty patients with bilateral mandibular impacted teeth were selected, and were randomly divided into dexketoprofen tromethamine group(experimental group) and placebo group(control group). The pain scores of patients at 0.5, 2, 4, 8, 12, and 24 hours after tooth extraction were counted by numeric rating scale(NRS), and the total dosage of emergent analgesic drugs used in 24 hours was recorded. COX analysis method was used to compare the interval time and the number of cases of first application of emergent analgesic drugs after two operations, and the survival curve was drawn. SPSS 20.0 software package was used for data analysis. RESULTS: The NRS scores of postoperative pain in the experimental group were significantly lower than those in the control group at 2, 4, 8 and 12 hours after operation (P<0.05). The dose of emergent analgesics used in the experimental group for 24 h was significantly lower than that in the control group (P<0.05). Survival curve showed that the interval time between the first application of analgesics in the experimental group was significantly longer than that in the control group(P<0.05). CONCLUSIONS: Dexketoprofen tromethamine can achieve obvious analgesic effect within 12 hours, but the analgesic effect is not obvious after 12 hours.

Key words: Dexketoprofen tromethamine, Extraction of impacted teeth, Preemptive analgesia, Numeric rating scale

中图分类号:

R782.1

赵君, 吴晓波, 刘娜, 周瑜, 郝新河. 口服右旋酮洛芬氨丁三醇在阻生牙拔除术中的超前镇痛：随机对照双盲试验[J]. 上海口腔医学, 2023, 32(3): 298-301.

ZHAO Jun, WU Xiao-bo, LIU Na, ZHOU Yu, HAO Xin-he. Oral dexketoprofen tromethamine for preemptive analgesia in extraction of impacted teeth: a randomized controlled double-blind trial[J]. Shanghai Journal of Stomatology, 2023, 32(3): 298-301.

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口服右旋酮洛芬氨丁三醇在阻生牙拔除术中的超前镇痛：随机对照双盲试验

Oral dexketoprofen tromethamine for preemptive analgesia in extraction of impacted teeth: a randomized controlled double-blind trial

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