cN0期舌鳞癌患者颈淋巴结转移的相关因素及预后分析

doi:10.19439/j.sjos.2022.05.017

上海口腔医学 ›› 2022, Vol. 31 ›› Issue (5): 540-543.doi: 10.19439/j.sjos.2022.05.017

cN0期舌鳞癌患者颈淋巴结转移的相关因素及预后分析

叶璞^1,*, 黄兴鸿^2,*, 张伟¹, 吴萌¹, 俞辉明¹

1.南京医科大学附属淮安市第一人民医院口腔颌面外科,2.影像中心,江苏淮安 223399

收稿日期:2022-05-27 修回日期:2022-07-04 出版日期:2022-10-25 发布日期:2022-11-01
通讯作者: 俞辉明,E-mail: yhm2277544083@163.com
作者简介:叶璞（1994-）,女,在读硕士研究生,E-mail: yp876477062@163.com;黄兴鸿（1993-）,硕士,住院医师,E-mail: hxh_woyez@163.com。^*并列第一作者

Related factors of cervical lymph node metastasis, prognosis of patients with cN0tongue squamous cell carcinoma

YE Pu¹, HUANG Xing-hong², ZHANG Wei¹, WU Meng¹, YU Hui-ming¹

1. Department of Oral and Maxillofacial Surgery, 2. Department of Radiology, Affiliated Huaian No.1 People's Hospital of Nanjing Medical University. Huaian 223399, Jiangsu Province, China

Received:2022-05-27 Revised:2022-07-04 Online:2022-10-25 Published:2022-11-01

摘要/Abstract

摘要： 目的: 探讨cN0期舌鳞癌患者颈淋巴结转移的相关因素及术后生存质量,为临床预测颈部隐匿性转移及提高生存率提供理论依据。方法: 收集南京医科大学附属淮安第一医院cN0期舌鳞癌患者283例,通过卡方检验及Logistic回归分析颈淋巴结转移与患者临床病理参数之间的相关性,通过单因素及多因素Cox回归分析探讨舌鳞癌患者预后的独立危险因素,通过生存分析研究颈淋巴结转移与患者预后之间的相关性。采用SPSS 21.0软件包对数据进行统计学分析。结果: 卡方检验及Logistic回归分析表明,浸润深度、T分期、病理学分级与颈淋巴结转移密切相关（P<0.05）,而浸润深度是导致术后颈淋巴结转移的主要因素（OR=2.175）;浸润深度、病理分级及颈淋巴结转移与舌鳞癌患者预后密切相关（P<0.05）。结论: 浸润深度、T分期、病理学分级可作为预测cN0期舌鳞癌隐匿性颈淋巴结转移的指标,浸润深度、病理分级及颈淋巴结转移可作为预测cN0期舌鳞癌患者预后的指标。

关键词: 舌鳞癌, 隐匿性转移, 浸润深度, 预后

Abstract: PURPOSE: To explore the related factors of cervical lymph node metastasis and postoperative quality of life in patients with cN0 tongue squamous cell carcinoma (SCC), and provide a theoretical basis for clinical prediction of occult neck metastasis and improvement of survival rate. METHODS: A total of 283 patients with cN0 tongue SCC who underwent surgery in Huaian No.1 People’s Hospital were collected. Chi-square test and logistic regression were used to analyze the correlation between cervical lymph node metastasis and clinical pathological parameters of patients. Single-factor and multi-factor Cox regression analysis were used to explore independent risk factors for prognosis of patients with tongue SCC. Survival analysis was used to study the correlation between cervical lymph node metastasis and prognosis of patients. SPSS 21.0 software package was used for statistical analysis. RESULTS: Chi-square test and logistic regression analysis showed that infiltration depth, T stage and pathological grade were closely related to cervical lymph node metastasis(P<0.05), and infiltration depth was the main factor leading to postoperative cervical lymph node metastasis(OR=2.175). The depth of invasion, pathological grade and cervical lymph node metastasis could be regarded as independent risk factor affecting the prognosis of patients with tongue SCC(P<0.05). CONCLUSIONS: Invasion depth, T stage and pathological grade can be used as indicators to predict occult cervical lymph node metastasis in patients with cN0 tongue SCC. Invasion depth, pathological grade and cervical lymph node metastasis can be used as independent indicators to predict the prognosis of patients with cN0 tongue SCC.

Key words: Tongue squamous cell carcinoma, Occult metastasis, Invasion depth, Prognosis

中图分类号:

R739.8

叶璞, 黄兴鸿, 张伟, 吴萌, 俞辉明. cN0期舌鳞癌患者颈淋巴结转移的相关因素及预后分析[J]. 上海口腔医学, 2022, 31(5): 540-543.

YE Pu, HUANG Xing-hong, ZHANG Wei, WU Meng, YU Hui-ming. Related factors of cervical lymph node metastasis, prognosis of patients with cN0tongue squamous cell carcinoma[J]. Shanghai Journal of Stomatology, 2022, 31(5): 540-543.

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cN0期舌鳞癌患者颈淋巴结转移的相关因素及预后分析

Related factors of cervical lymph node metastasis, prognosis of patients with cN0tongue squamous cell carcinoma

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