Nd:YAG激光联合白芍总苷胶囊治疗糜烂型口腔扁平苔藓的疗效观察

上海口腔医学 ›› 2016, Vol. 25 ›› Issue (4): 481-483.

Nd:YAG激光联合白芍总苷胶囊治疗糜烂型口腔扁平苔藓的疗效观察

胡爱平, 刘宗响

徐州市口腔医院口腔黏膜病科,江苏徐州 221002

收稿日期:2015-07-29 出版日期:2016-08-25 发布日期:2016-09-06
通讯作者: 刘宗响,E-mail：xzkqlzx@163.com
作者简介:胡爱平（1969-）,女,学士,副主任医师,

Clinical effect of Nd:YAG laser combined with total glucosides of paeony for the treatment of erosive oral lichen planus

HU Ai-ping, LIU Zong-xiang

Department of Oral Mucosal Diseases, Xuzhou Stomatological Hospital. Xuzhou 221002, Jiangsu Province, China

Received:2015-07-29 Online:2016-08-25 Published:2016-09-06

摘要/Abstract

摘要： 目的观察Nd:YAG激光与白芍总苷胶囊联合治疗糜烂型口腔扁平苔藓(oral lichen planus,OLP)的临床疗效。方法采用随机数字表法将60例OLP患者分为观察组（28例）和对照组（32例）。2组患者均口服白芍总苷胶囊,观察组辅以Nd:YAG激光照射。于治疗前、治疗后3个月对2组患者的临床疗效进行比较,采用SPPS17.0软件包对数据进行统计学分析。结果治疗3个月后发现观察组VAS及体征评分（分别为1.36±1.39分、2.32±1.56分）及对照组VAS及体征评分（分别为2.75±1.67分、3.66±1.33分）均显著优于治疗前 (P<0.05),观察组患者VAS及体征评分均显著优于对照组(P<0.05);观察组治疗有效率为82.1%,显著高于对照组的53.1%(P<0.05)。结论Nd:YAG激光联合口服白芍总苷胶囊能够显著提高糜烂型OLP的疗效,且安全性良好,值得临床推广应用。

关键词: Nd:YAG激光, 口腔扁平苔藓, 白芍总苷, 糜烂

Abstract: PURPOSE: To investigate the clinical effect of Nd:YAG laser combined with total glucosides of paeony (TGP) taken orally for the treatment of erosive oral lichen planus (OLP). METHODS: Sixty patients who were diagnosed as erosive OLP with clinical symptoms were divided into experimental group (n=28) and control group (n=32) using a random number table. All patients received TGP while the patients in the experimental group were given Nd:YAG laser irradiation. The clinical effects were evaluated 3 months after treatment. The data were analyzed using SPSS 17.0 software package. RESULTS: Three months later, the average VAS score and sign score had improved significantly to (1.36±1.39) and (2.32±1.56) in the experimental group. The same tendency was observed in the control group and at the time point no significant difference was observed between the experimental group and the control group. The effectiveness of the experimental group was significantly higher than the control group (82.1% vs 53.1%). CONCLUSIONS: Nd: YAG laser combined with TGP can improve the efficacy of erosive OLP. The regime is safe and effective, which is worth of wide clinical application.

Key words: Nd:YAG laser, Oral lichen planus, Total glucosides of paeony, Erosive

中图分类号:

R781.5

胡爱平, 刘宗响. Nd:YAG激光联合白芍总苷胶囊治疗糜烂型口腔扁平苔藓的疗效观察[J]. 上海口腔医学, 2016, 25(4): 481-483.

HU Ai-ping, LIU Zong-xiang. Clinical effect of Nd:YAG laser combined with total glucosides of paeony for the treatment of erosive oral lichen planus[J]. Shanghai Journal of Stomatology, 2016, 25(4): 481-483.

参考文献

[1] Parashar P. Oral lichen planus [J]. Otolaryngol Clin North Am, 2011, 44 (1): 89-107.
[2] Xue J, Fan MW, Wang SZ, et al. A clinical study of 674 patients with oral lichen planus in China [J]. J Oral Pathol Med, 2005, 34 (8): 467-472.
[3] Payeras MR, Cherubini K, Figueiredo MA, et al. Oral lichen planus: focus on etiopathogenesis [J]. Arch Oral Biol, 2013, 58(9): 1057-1069.
[4] Lodi G, Scully C, Carrozzo M, et al. Current controversies in oral lichen planus: report of an international consensus meeting. Part 1.Viral infections and etiopathogenesis [J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2005, 100(1): 40-51.
[5] 周威. 口腔扁平苔藓[C]//陈谦明. 口腔黏膜病学[M]. 第3版. 北京: 人民卫生出版社, 2008: 101-107.
[6] 蒋红柳, 王文梅, 段宁, 等. Er：YAG激光和Nd：YAG激光联合应用治疗口腔均质型白斑[J]. 临床口腔医学杂志, 2014, 30(12): 745-747.
[7] 周刚, 刘宏伟, 林梅, 等. 口腔扁平苔藓(萎缩型、糜烂型)疗效评价标准(试行) [J]. 中华口腔医学杂志, 2005, 40(2): 92-93.
[8] 章金鹤, 周曾同. 口腔扁平苔藓724例的回顾性分析 [J]. 中华口腔医学杂志, 2007, 42(11): 699-671.
[9] Carbone M, Arduino PG, Carrozzo M, et al. Topical clobetasol in the treatment of atrophic-erosive oral lichen planus: a randomized controlled trial to compare two preparations with different concentrations [J]. J Oral Pathol Med, 2009, 38(2): 227-233.
[10] Dillenburg CS, Martins MA, Munerato MC, et al. Efficacy of laser phototherapy in comparison to topical clobetasol for the treatment of oral lichen planus: a randomized controlled trial [J]. J Biomed Opt, 2014, 19(6): 068002.
[11] 邱宏亮. 半导体激光治疗糜烂型口腔扁平苔藓的疗效观察 [J]. 中华物理医学与康复杂志, 2010, 32(5): 387-388.
[12] 杨在富, 杨景庚, 高光煌. 低能量激光免疫调节作用研究进展 [J]. 中华理疗杂志, 2001, 24(4): 244-247.
[13] 马丽, 李作孝. 白芍总苷的免疫调节功能及其临床应用 [J]. 中国实验方剂学杂志, 2010, 16(17): 244-246.
[14] 杜岩, 庞劲凡, 欧龙, 等. 复方维甲酸软膏联合白芍总苷胶囊治疗斑纹型口腔扁平苔藓半年疗效观察 [J]. 中华口腔医学杂志, 2012, 47(z1): 118-122.
[15] Cafaro A, Arduino PG, Massolini G, et al. Clinical evaluation of the efficiency of low-level laser therapy for oral lichen planus: a prospective case series [J]. Lasers Med Sci, 2014, 29(1): 185-190.