SD大鼠咬合创伤模型的建立

上海口腔医学 ›› 2016, Vol. 25 ›› Issue (3): 281-283.

SD大鼠咬合创伤模型的建立

忻贤贞¹, 杨旭¹, 魏斌²

1.上海交通大学医学院附属第九人民医院·口腔医学院口腔修复科;
2.口腔特需门诊,上海市口腔医学重点实验室,上海 200011

收稿日期:2015-07-01 修回日期:2015-09-21 出版日期:2016-06-25 发布日期:2016-07-22
通讯作者: 魏斌, E-mail: weibin0328@hotmail.com E-mail:185819248@qq.com
作者简介:忻贤贞（1986-）,女,硕士,住院医师
基金资助:
上海市科学技术委员会资助项目（12441903001,13140902701）

Establishment of traumatic occlusion model in Sprague-Dawley rats

XIN Xian-zhen¹, YANG Xu¹, WEI Bin²

1. Department of Prosthodontics;
2. Department of Stomatology Special Consultation Clinic, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine Shanghai Key Laboratory of Stomatology. Shanghai 200011, China

Received:2015-07-01 Revised:2015-09-21 Online:2016-06-25 Published:2016-07-22

摘要/Abstract

摘要： 目的观察并筛选得到最有效诱导SD大鼠咬合创伤的建模方法。方法选用实验级雄性SD大鼠,体重150~200 g,鼠龄10~12周。麻醉后,在其上颌后牙分别用Super-bond和Multi-link粘结不锈钢方丝、树脂、铸造半冠、铸造半冠联冠、使用选择性激光熔积（selective laser melting,SLM）技术制作的半冠、SLM半冠联冠。粘结后,每天观察实验装置脱落率。采用SAS8.2软件包的Fisher精确概率法,分析不同方法之间的差异。结果采用Super-bond或Multi-link 2种方式,对脱落率的影响无显著差异。在黏结方式不影响脱落率的前提下,分析不同实验装置之间对脱落率的影响,组间差异具有显著性（P<0.0001）。结论应用SLM技术制作的修复体,在SD大鼠咬合创伤模型中诱导咬合高点是有效的、可行的。

关键词: 咬合创伤, SD大鼠, 实验模型

Abstract: PURPOSE: In this study, different methods were used to observe and obtain the most effective one to establish occlusal trauma model in Sprague-Dawley rats. METHODS: SPF male SD rats weighing 150~200 g and aged 10 to 12 weeks were used in this study. The rats' maxillary molars were bonded with stainless steel wire, resin , casting half crown , casting half combined crowns, half crown using selective laser melting (SLM) technology, half combined crowns using SLM technology through Super-bond and Multi-link bonding under general anesthesia. After bonding, the experimental device expulsion rates were observed daily. The data was analyzed statistically using Fisher's exact test with SAS 8.2 software package. RESULTS: There was no significant difference between the falling rates of using super-bond and using multi-link. Under the situation in which different bonding methods exerted no influence on the falling rates, there was significant difference between different experimental devices (P<0.0001). CONCLUSIONS: The restorations fabricated with SLM technology is valid and feasible to induce occlusal point in building occlusal trama model using SD rats.

Key words: Traumatic occlusion, SD rats, Experimental model

中图分类号:

R783.2

忻贤贞, 杨旭, 魏斌. SD大鼠咬合创伤模型的建立[J]. 上海口腔医学, 2016, 25(3): 281-283.

XIN Xian-zhen, YANG Xu, WEI Bin. Establishment of traumatic occlusion model in Sprague-Dawley rats[J]. Shanghai Journal of Stomatology, 2016, 25(3): 281-283.

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