中药-壳聚糖混合物对白念菌的抑菌效果及作为义齿稳固剂的可行性

上海口腔医学 ›› 2015, Vol. 24 ›› Issue (2): 188-192.

中药-壳聚糖混合物对白念菌的抑菌效果及作为义齿稳固剂的可行性

李律,孟贺,李金源,吴文慧,梁锐英

河北联合大学口腔医学院修复教研室,河北唐山 063000

收稿日期:2014-10-15 出版日期:2015-04-20 发布日期:2015-07-24
通讯作者: 孟贺,Tel: 0315-3721586,E-mail:menghe10.2@163.com
作者简介:李律(1988-),女,硕士研究生,E-mail:873569152@qq.com

Study on antimicrobial effect of the mixture of Chinese medicine-chitosan to Candida albicans and the possibility as denture adhesive

LI Lv,MENG He,LI Jin-yuan,WU Wen-hui,LIANG Rui-ying

Department of Prosthodontics, School of Stomatology, Hebei United University. Tangshan 063000, Hebei Province, China

Received:2014-10-15 Online:2015-04-20 Published:2015-07-24

摘要/Abstract

摘要： 目的观察加入不同中药后的水溶性壳聚糖对白念菌的抑菌效果及其作为义齿稳固剂的黏结抗张强度。方法采用水煎法将6种中药提纯并烘干,配制成不同浓度,分别与壳聚糖混合,筛选最有效抑制白念菌的混合物及其最小抑菌浓度（MIC）;测定此种混合物的黏结抗张强度值,并与Protefix义齿稳固剂进行比较。采用SPSS17.0软件包对数据进行统计学分析。结果6种中药-壳聚糖混合物中,以七叶一枝花-壳聚糖混合物抗菌效果最佳,其MIC为1.563 mg/mL;七叶一枝花的黏结抗张强度值在0 h及浸入人工唾液后12 h大于protefix义齿稳固剂,其平均值及最大值大于Protefix义齿稳固剂（P<0.05）。结论七叶一枝花-壳聚糖混合物具有良好的抑制白念菌效果及黏结抗张强度。

关键词: 中药, 白念菌, 黏结抗张强度, 义齿稳固剂

Abstract: PURPOSE: To observe the antimicrobial effect and the tensile bond strength of water-soluble chitosan after adding different Chinese medicines to Candida albicans. METHODS: The extract of 6 kinds of Chinese medicine by decoction in different concentrations were mixed with chitosan, and the most effective mixture inhibiting Candida albicans and the minimal inhibitory concentration (MIC) were explored; Then the tensile bond strength of the mixture was tested and compared with Protefix denture adhesive. The data was analyzed with SPSS17.0 software package. RESULTS: The antibacterial effect of polyphylla-chitosan mixture was the best among the 6 kinds of Chinese medicine- chitosan mixture, and its MIC was 1.563 mg/mL. The tensile bond strength of polyphylla-chitosan mixture at 0 h and 12 h when immersed in artificial saliva were significantly larger than Protefix denture adhesive. The average value and the maximum value was significantly greater than the Protefix denture adhesive (P<0.05). CONCLUSIONS: Polyphylla-chitosan mixture has good antibacterial effect on Candida albicans and large tensile bond strength.

Key words: Traditional Chinese medicine, Candida albicans, Tensile bond strength, Denture adhesive

中图分类号:

R783.1

李律,孟贺,李金源,吴文慧,梁锐英. 中药-壳聚糖混合物对白念菌的抑菌效果及作为义齿稳固剂的可行性[J]. 上海口腔医学, 2015, 24(2): 188-192.

LI Lv,MENG He,LI Jin-yuan,WU Wen-hui,LIANG Rui-ying. Study on antimicrobial effect of the mixture of Chinese medicine-chitosan to Candida albicans and the possibility as denture adhesive[J]. Shanghai Journal of Stomatology, 2015, 24(2): 188-192.

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