盘状结构域受体1与基质金属蛋白酶2在唾液腺腺样囊性癌中的表达及意义

上海口腔医学 ›› 2015, Vol. 24 ›› Issue (3): 326-330.

盘状结构域受体1与基质金属蛋白酶2在唾液腺腺样囊性癌中的表达及意义

王智明¹,叶明¹,张雨霏¹,杨东升¹,马颖²,周卓³,张力平¹,刘维贤¹

1.中国医科大学附属盛京医院口腔颌面外科,辽宁沈阳 110004;
2. 中国医科大学附属盛京医院病理科,辽宁沈阳 110004;
3. 中心实验室,辽宁沈阳 110004

收稿日期:2014-11-17 出版日期:2015-06-20 发布日期:2015-07-24
通讯作者: 王智明, E-mail:wangzm@sj-hospital.org
作者简介:王智明（1972-）,男,博士,副教授,硕士生导师
基金资助:
辽宁省科学技术计划资助项目（2012225100）

Expressions of discoidin domain receptor 1 and matrix metalloproteinase 2 in salivary gland adenoid cystic carcinoma and clinical significance

WANG Zhi-ming¹,YE Ming¹,ZHANG Yu-fei¹,YANG Dong-sheng¹,MA Ying²,ZHOU Zhuo³,ZHANG Li-ping¹,LIU Wei-xian¹

1.Department of Oral and Maxillofacial Surgery, Shengjing Hospital of China Medical University. Shengyang 110004, Liaoning Province, China;
2.Department of Pathology, Shengjing Hospital of China Medical University. Shengyang 110004, Liaoning Province, China;
3.Department of Laboratory Center, Shengjing Hospital of China Medical University. Shengyang 110004, Liaoning Province, China

Received:2014-11-17 Online:2015-06-20 Published:2015-07-24
Supported by:
Research Fund of Science and Technology Project of Liaoning Province （2012225100）

摘要/Abstract

摘要： 目的:检测唾液腺腺样囊性癌(salivary gland adenoid cystic carcinoma, SACC）组织中盘状结构域受体1（discoidin domain receptor 1,DDR1）与基质金属蛋白酶2（matrix metalloproteinase 2,MMP2）的表达,探讨两者在SACC中的表达意义及相关性。方法:应用SP免疫组织化学方法检测54例SACC标本和30例正常唾液腺组织中DDR1与MMP2的表达情况。采用SPSS13.0软件包对数据进行统计学分析。结果:DDR1在SACC中的阳性表达率为87.0%,显著高于正常唾液腺组织（10%,P<0.01）。DDR1的高表达与SACC的神经侵袭、淋巴结转移相关（P<0.05）。MMP2在SACC中的阳性表达率为68.5%,显著高于正常唾液腺组织（13.3%,P<0.01）。经Spearman等级相关分析,DDR1与MMP2呈现显著正相关（r=0.332, P<0.05）。结论:在SACC中,DDR1与MMP2共同高表达,与SACC的发生与发展相关。

关键词: 盘状结构域受体1, 基质金属蛋白酶2, 唾液腺, 腺样囊性癌

Abstract: PURPOSE: To investigate the expressions of discoidin domain receptor 1(DDR1) and matrix metalloproteinase 2(MMP2) in salivary gland adenoid cystic carcinoma（SACC） and discuss their significance and correlations with clinicopathological parameters. METHODS: SP immunohistochemical method was used to detect the expressions of DDR1 and MMP2 in 54 samples of SACC and 30 normal salivary gland samples. SPSS 13.0 software package was used for statistical analysis. RESULTS: The positive expression rate of DDR1 in SACC was 87.0%, which was significantly higher than that in normal salivary gland tissues(10.0%, P<0.01). The positive expression of DDR1 was related with neural invasion and lymph node metastasis (P<0.05). The positive expression rate of MMP2 was 68.5% in SACC, which was significantly higher than that in normal group(13.3%, P<0.01). The expression of DDR1 was positively correlated with MMP2 by Spearman rank analysis(r=0.332, P<0.05). CONCLUSIONS: High expressions of DDR1 and MMP2 correlate with carcinogenesis and progress of SACC.

Key words: Discoidin domain receptor 1, Matrix metalloproteinase 2, Salivary gland, Adenoid cystic carcinoma

中图分类号:

R739.8

王智明,叶明,张雨霏,杨东升,马颖,周卓,张力平,刘维贤. 盘状结构域受体1与基质金属蛋白酶2在唾液腺腺样囊性癌中的表达及意义[J]. 上海口腔医学, 2015, 24(3): 326-330.

WANG Zhi-ming,YE Ming,ZHANG Yu-fei,YANG Dong-sheng,MA Ying,ZHOU Zhuo,ZHANG Li-ping,LIU Wei-xian. Expressions of discoidin domain receptor 1 and matrix metalloproteinase 2 in salivary gland adenoid cystic carcinoma and clinical significance[J]. Shanghai Journal of Stomatology, 2015, 24(3): 326-330.

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