脱细胞真皮基质与腮腺咬肌筋膜下翻瓣预防Frey综合征的meta分析

上海口腔医学 ›› 2014, Vol. 23 ›› Issue (5): 628-633.

脱细胞真皮基质与腮腺咬肌筋膜下翻瓣预防Frey综合征的meta分析

肖孟^{1, 2}, 石亮¹, 刘云生^{1, 2}

1.山东大学齐鲁医院口腔颌面外科,山东大学口腔医学研究所,山东济南 250012; 2.山东大学口腔医学院,山东省口腔生物医学重点实验室,山东济南 250012

收稿日期:2013-09-29 修回日期:2013-11-06 出版日期:2014-10-20 发布日期:2015-02-04
通讯作者: 石亮,Tel:0531-82166772,E-mail：shiliang1976@126.com
作者简介:肖孟（1987-）,男,硕士,E-mail：xiaomeng70001@126.com
基金资助:
山东省自然科学基金（ZR2010HM037）

Effectiveness of acellular dermal matrix and parotid fascia in preventing Frey’s syndrome: meta analysis

XIAO Meng^{1, 2}, SHI Liang², LIU Yun-sheng^{1, 2}

1.School of Stomatology of Shandong University, Shandong Provincial Key Laboratory of Oral Biomedicine. Jinan 250012; 2. Department of Oral and Maxillofacial Surgery, Qilu Hospital, Shandong University; Stomatology Center of Shandong University. Jinan 250012, Shandong Province, China

Received:2013-09-29 Revised:2013-11-06 Online:2014-10-20 Published:2015-02-04

摘要/Abstract

摘要： 目的：系统评价并比较脱细胞真皮基质（ADM）和腮腺咬肌筋膜下翻瓣预防Frey综合征的有效性。方法检索2001—2013年间万方数据库、中国学术期刊全文数据库(CNKI)、维普数据库(VIP)及中国生物医学文献数据库(CBM)所收录的有关腮腺咬肌筋膜下翻瓣和（或）ADM预防腮腺良性肿瘤术后Frey综合征的随机对照研究（RCT）。采用Review Manager 5.2软件对纳入文献的数据进行meta分析。结果共纳入RCT 16篇。Meta分析显示,采用腮腺咬肌筋膜下翻瓣和术中植入ADM,术后Frey综合征的主观发生率分别降低71%和87%,客观发生率分别降低64%和85%。在主观发生率降低方面,两者之间无显著差异,而术中植入ADM比腮腺咬肌筋膜下翻瓣能更为有效地降低术后Frey综合征的客观发生率,差异具有显著性。结论本研究显示,腮腺良性肿瘤一般可通过腮腺咬肌筋膜下翻瓣预防术后Frey综合征的发生;而对于无法保留腮腺咬肌筋膜者,同期植入ADM,同样能达到预防术后Frey综合征的目的。

关键词: 脱细胞真皮基质, 腮腺咬肌筋膜, Frey综合征, Meta分析

Abstract: PURPOSE: To evaluate and compare the effectiveness of acellular dermal matrix (ADM) and parotid fascia in preventing Frey’s syndrome. METHODS: A literature research was performed using Wanfang Database, Chinese Biological Literature Database, China National Knowledge Infrastructure and Chinese Scientific Journals database of VIP from 2001 to 2013. Relative ratio (RR) was calculated and meta analysis was performed by Review Manager 5.2. RESULTS: A total of 16 controlled studies were included. Meta analysis showed that the use of ADM and preservation of the parotid fascia could significantly reduce the risk of Frey’s syndrome. The subjective incidence was decreased by 71% and 87%, and objective incidence was reduced by 64% and 85%, respectively. Significant difference was found between ADM and parotid fascia in reducing subjective incidence, in which ADM seemed to be more effective. CONCLUSIONS: The present study suggested that parotid fascia should be adopted as an effective method to reduce Frey’s syndrome in most circumstances for patients with benign parotid tumors. For those whose parotid fascia could not be preserved, ADM might be another good choice.

Key words: Acellular dermal matrix, Parotid fascia, Frey’s syndrome, Meta analysis

肖孟, 石亮, 刘云生. 脱细胞真皮基质与腮腺咬肌筋膜下翻瓣预防Frey综合征的meta分析[J]. 上海口腔医学, 2014, 23(5): 628-633.

XIAO Meng, SHI Liang, LIU Yun-sheng. Effectiveness of acellular dermal matrix and parotid fascia in preventing Frey’s syndrome: meta analysis[J]. Shanghai Journal of Stomatology, 2014, 23(5): 628-633.

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