上海口腔医学

上海口腔医学 ›› 2026, Vol. 35 ›› Issue (4): 388-392.doi: 10.19439/j.sjos.2026.04.007

• 论著 • 上一篇    下一篇

医用胶原蛋白海绵在下颌阻生牙微创拔除中的应用效果评价

吕丽敏, 丁有彪, 刘然   

  1. 天津市第三中心医院分院 口腔科,天津 300250
  • 收稿日期:2025-05-16 修回日期:2025-09-16 出版日期:2026-08-25 发布日期:2026-09-01
  • 通讯作者: 刘然,E-mail: lysimple@163.com
  • 作者简介:吕丽敏（1987—）,女,学士,主治医师,E-mail: afgasgag@163.com
  • 基金资助:
    天津市自然科学基金（21JCYBJC01340）

Evaluation of the effect of medical collagen sponge in minimally invasive extraction of impacted mandibular teeth

Lyu Limin, Ding Youbiao, Liu Ran   

  1. Department of Stomatology, Tianjin Third Central Hospital Branch. Tianjin 300250,China
  • Received:2025-05-16 Revised:2025-09-16 Online:2026-08-25 Published:2026-09-01

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摘要： 目的: 评价医用胶原蛋白海绵在下颌阻生牙微创拔除中的应用效果。方法: 选择2021年12月—2024年12月收治的88例下颌阻生牙患者,采用信封抽签法随机分为对照组（n=44）和试验组（n=44）。两组均采用高速涡轮钻分牙+微创牙挺拔牙法拔除患牙,对照组拔牙创进行常规处理,试验组覆盖医用胶原蛋白海绵。比较两组术后出血情况、疼痛视觉模拟评分法（visual analogue scale,VAS）评分、开口受限程度、炎性因子水平及并发症发生情况。结果: 试验组显著出血比例显著低于对照组,无出血比例显著高于对照组（P<0.05）。术后24、72 h,试验组VAS 评分显著低于对照组（P<0.05）。试验组术后开口受限正常比例显著高于对照组,重度受限比例显著低于对照组（P<0.05）。试验组C反应蛋白（C-reactive protein,CRP）、白细胞介素6（interleukin-6,IL-6）和白细胞介素8（interleukin-8,IL-8）水平显著低于对照组（P<0.05）,并发症发生率显著低于对照组（P<0.05）。结论: 医用胶原蛋白海绵应用于下颌阻生牙微创拔除术,不仅在止血、减轻疼痛、缓解开口受限等方面效果良好,还可有效抑制术后炎症反应,降低并发症发生率。

关键词: 医用胶原蛋白海绵, 微创拔牙法, 下颌阻生牙, 开口受限

Abstract: PURPOSE: To evaluate the effect of medical collagen sponge in minimally invasive extraction of impacted mandibular teeth. METHODS: A total of 88 patients with impacted mandibular teeth admitted from December 2021 to December 2024 were selected and randomly divided into the control group (n=44) and the experimental group (n=44) by envelope lottery. Both groups adopted the method of high-speed turbine drilling for tooth separation and minimally invasive tooth augmentation to extract the affected teeth. The extraction wounds of the control group were treated conventionally, while those of the experimental group were covered with medical collagen sponges. Postoperative bleeding status, visual analogue scale (VAS) scores of pain, degree of mouth opening limitation, inflammatory cytokine levels and complications were compared between the two groups. RESULTS: The proportion of significant bleeding in the experimental group was significantly lower than that in the control group, while the proportion of no bleeding was significantly higher than that in the control group (P<0.05). At 24 and 72 hours after the operation, the pain VAS score of the experimental group was significantly lower than that of the control group (P<0.05). The proportion of normal postoperative opening restriction in the experimental group was significantly higher than that in the control group, and the proportion of severe restriction was significantly lower than that in the control group (P<0.05). Levels of C-reactive protein (CRP), interleukin-6 (IL-6), and interleukin-8 (IL-8) in the experimental group were significantly lower than those in the control group (P<0.05). The incidence of complications in the experimental group was also significantly lower (P<0.05). CONCLUSIONS: Medical collagen sponge is applied in minimally invasive extraction of impacted mandibular teeth with good outcomes. It not only has excellent effects in hemostasis, pain relief and relief of restricted opening, but also can effectively inhibit postoperative inflammatory responses and reduce the incidence of complications.

Key words: Medical collagen sponge, Minimally invasive tooth extraction method, Impacted mandibular teeth, Mouth opening limitation

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