富自体浓缩生长因子纤维蛋白液联合Bio-Oss骨粉对口腔种植引导性骨再生术后黏膜愈合和骨缺损再生的影响

doi:10.19439/j.sjos.2020.03.017

上海口腔医学 ›› 2020, Vol. 29 ›› Issue (3): 316-320.doi: 10.19439/j.sjos.2020.03.017

富自体浓缩生长因子纤维蛋白液联合Bio-Oss骨粉对口腔种植引导性骨再生术后黏膜愈合和骨缺损再生的影响

林勇¹, 毛驰², 侯丹¹, 常晓荣¹, 张军华¹, 赵献银¹

1.新乡医学院附属濮阳市油田总医院口腔科,河南濮阳 457001;
2.北京大学口腔医院口腔颌面外科,北京 100081

收稿日期:2019-11-15 修回日期:2020-01-06 出版日期:2020-06-25 发布日期:2020-07-29
通讯作者: 毛驰,E-mail:908956635@qq.com
作者简介:林勇（1973-）,男,硕士,主任医师,E-mail：bebetolin@163.com

Effect of autologous concentrated growth factor fibrin solution combined with Bio-Oss bone powder on mucosal healing and bone regeneration after oral implanted guided bone regeneration

LIN Yong¹, MAO Chi², HOU Dan¹, CHANG Xiao-rong¹, ZHANG Jun-hua¹, ZHAO Xian-yin¹

1. Department of Stomatology, Puyang Oilfield General Hospital. Puyang 457001, Henan Province;
2. Department of Oral and Maxillofacial Surgery, Peking University Hospital of Stomatology. Beijing 100081, China

Received:2019-11-15 Revised:2020-01-06 Online:2020-06-25 Published:2020-07-29

摘要/Abstract

摘要： 目的探讨富自体浓缩生长因子纤维蛋白液联合Bio-Oss骨粉对口腔种植引导性骨再生术后黏膜愈合和骨缺损再生的影响。方法选择2016年10月—2018年12月濮阳市油田总医院口腔科接诊的83例上颌单个前牙缺失伴唇侧骨缺损患者,将其分为2组,实验组（42例）采用富自体浓缩生长因子纤维蛋白液+Bio-Oss骨粉引导骨再生,对照组（41例）采用Bio-Oss骨粉引导骨再生。随访2组患者术后7 d、6周、1年手术区黏膜愈合程度、种植体成功率、骨缺损再生情况、疼痛程度和其他并发症等的发生情况。观察2组种植体成功率和术后并发症,以及术后黏膜颜色、肿胀程度、出血指数、探诊深度、附着丧失、植骨高度、成骨厚度的差异。采用SPSS 25.0软件包对数据进行统计学分析。结果 2组种植体成功率无统计学差异（95.24% ∶ 97.56%,P>0.05）,实验组并发症发生率显著低于对照组（2.38% ∶ 14.63%,P<0.05）,实验组黏膜颜色、肿胀度评分显著低于对照组[（0.65±0.03）分 ∶ （2.01±0.15）分、（1.10±0.37）分 ∶ （2.69±0.54）分,P<0.05],出血指数、探诊深度、附着丧失显著低于对照组[（0.35±0.05） ∶ （0.49±0.09）、（3.39±0.62）mm ∶ （4.41±0.95）mm、（3.02±0.66）mm ∶ （5.31±0.91）mm,P<0.05],植骨高度、成骨高度显著高于对照组[（2.61±0.50）mm ∶ （2.20±0.31）mm、（2.53±0.34）mm ∶ （2.02±0.27）mm,P<0.05],实验组术后疼痛程度显著低于对照组（P<0.05）。结论富自体浓缩生长因子纤维蛋白液联合Bio-Oss骨粉可有效促进口腔种植引导骨再生术后黏膜愈合和骨缺损再生,减轻术后疼痛和并发症。

关键词: 富自体浓缩生长因子纤维蛋白液, Bio-Oss骨粉, 口腔种植引导性骨再生术, 黏膜愈合, 骨缺损再生

Abstract: PURPOSE: To investigate the effect of autologous concentrated growth factor fibrin solution combined with Bio-Oss bone powder on mucosal healing and bone regeneration after oral implanted guided bone regeneration. METHODS: From October 2016 to December 2018, 83 patients with maxillary single anterior tooth loss and labial bone defect were treated, they were divided into two groups. Patients in the experimental group (42 cases) received autologous concentrated growth factor fibrin solution + Bio-Oss bone powder, while patients in the control group (41 cases) received Bio-Oss bone powder alone. The degree of mucosal healing, implant success, bone defect regeneration, pain and other complications were followed up 7 days, 6 weeks and 1 year after operation. The success rate and complications of the two groups were observed, as well as the differences of mucosal color, swelling degree, bleeding index, depth of probing, attachment loss, height of bone graft and thickness of bone formation were measured and recorded. Statistical analysis was performed using SPSS 25.0 software package. RESULTS: There was no significant difference in the success rate of implants between the two groups (95.24% vs 97.56%, P>0.05). The complication rate of the experimental group was significantly lower than that of the control group (2.38% vs 14.63%, P<0.05). The mucosal color and swelling degree scores of the experimental group were significantly lower than those of the control group [(0.65±0.03) points vs (2.01±0.15) points, (1.10±0.37) points vs (2.69±0.54) points, P<0.05], and the bleeding index, probing depth, and attachment loss were significantly lower than the control group [(0.35±0.05) vs (0.49±0.09), (3.39±0.62) mm vs (4.41±0.95) mm, (3.02±0.66) mm vs (5.31±0.91) mm, P<0.05], bone graft height and osteogenesis height were significantly higher than the control group [(2.61±0.50) mm vs (2.20±0.31) mm, (2.53±0.34) mm vs (2.02±0.27) mm, P<0.05]. The degree of postoperative pain in the experimental group was significantly lower than that in the control group(P<0.05). CONCLUSIONS: Rich self-concentrating growth factor fibrin solution combined with Bio-Oss bone powder can effectively promote mucosal healing and bone regeneration after oral implant-guided bone regeneration, and reduce postoperative pain and complications.

Key words: Rich self-concentrating growth factor fibrin solution, Bio-Oss bone powder, Oral implant-guided bone regeneration, Mucosal healing, Bone defect regeneration

中图分类号:

R782.05

林勇, 毛驰, 侯丹, 常晓荣, 张军华, 赵献银. 富自体浓缩生长因子纤维蛋白液联合Bio-Oss骨粉对口腔种植引导性骨再生术后黏膜愈合和骨缺损再生的影响[J]. 上海口腔医学, 2020, 29(3): 316-320.

LIN Yong, MAO Chi, HOU Dan, CHANG Xiao-rong, ZHANG Jun-hua, ZHAO Xian-yin. Effect of autologous concentrated growth factor fibrin solution combined with Bio-Oss bone powder on mucosal healing and bone regeneration after oral implanted guided bone regeneration[J]. Shanghai Journal of Stomatology, 2020, 29(3): 316-320.

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富自体浓缩生长因子纤维蛋白液联合Bio-Oss骨粉对口腔种植引导性骨再生术后黏膜愈合和骨缺损再生的影响

Effect of autologous concentrated growth factor fibrin solution combined with Bio-Oss bone powder on mucosal healing and bone regeneration after oral implanted guided bone regeneration

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