二甲胺四环素联合茶多酚对早期种植体周围软组织炎患者IL-1β、IL-17F水平的影响

doi:10.19439/j.sjos.2019.05.009

上海口腔医学 ›› 2019, Vol. 28 ›› Issue (5): 494-498.doi: 10.19439/j.sjos.2019.05.009

二甲胺四环素联合茶多酚对早期种植体周围软组织炎患者IL-1β、IL-17F水平的影响

李宇崚¹, 王卫忠², 龚忠诚³

1.新疆伊犁哈萨克自治州奎屯医院口腔修复科,新疆奎屯 833200;
2.新疆伊犁哈萨克自治州奎屯医院设备科,新疆奎屯 833200;
3.新疆医科大学第一附属医院口腔颌面外科,新疆乌鲁木齐 830054

收稿日期:2019-05-20 出版日期:2019-10-25 发布日期:2019-12-11
通讯作者: 龚忠诚,E-mail：565249755@qq.com
作者简介:李宇崚（1975-）,女,本科,副主任医师, E-mail：10750256@qq.com
基金资助:
奎屯市科技计划项目（201929）

Effects of dimethylamine tetracycline combined with tea polyphenols on the levels of IL-1β and IL-17F in patients with early peri-implant soft tissue inflammation

LI Yu-leng¹, WANG Wei-zhong², GONG Zhong-cheng³

1.Department of Stomatology, Kuitun Hospital, Yili Kazak Autonomous Prefecture.Kuitun 833200;
2.Department of Equipment, Kuitun Hospital, Yili Kazak Autonomous Prefecture.Kuitun 833200;
3.Department of Oral and Maxillofacial Surgery, First Affiliated Hospital of Xinjiang Medical University.Urumqi 830054, Xinjiang Uygur Autonomous Region, China

Received:2019-05-20 Online:2019-10-25 Published:2019-12-11

摘要/Abstract

摘要： 目的研究二甲胺四环素联合茶多酚对早期种植体周围软组织炎患者白细胞介素1β（interleukin-1 β,IL-1β）、白细胞介素17F（interleukin-17F,IL-17F）水平的影响。方法选取2016年5月—2018年5月在新疆伊犁哈萨克自治州奎屯医院和新疆医科大学第一附属医院就诊的早期种植体周围软组织炎患者96例,按照随机数字法分为二甲胺四环素组和联合组（每组48例）。二甲胺四环素组患者给予盐酸二甲胺四环素软膏治疗,联合组在二甲胺四环素组的基础上给予茶多酚治疗。检测治疗前后的菌斑指数（plaque index,PLI）、龈沟出血指数（sulcus bleeding index,SBI）、附着丧失（attachment loss,AL）、龈沟液（gingival crevicular fluid,GCF）、探诊深度（probing depth,PD）、IL-1β和IL-17F水平,采用SPSS 20.0软件包对数据进行统计学分析。结果 2组患者治疗后PLI、SBI、AL、GCF、PD指标显著低于治疗前（P<0.05）。联合组患者治疗后,PLI、SBI、AL、GCF、PD指标水平低于二甲胺四环素组治疗后（P<0.05）。2组患者治疗后,IL-1β、IL-17F水平低于2组治疗前（P<0.05）。联合组患者治疗后,IL-1β、IL-17F水平低于二甲胺四环素组治疗后（P<0.05）。联合组患者治疗有效率为93.75%,显著高于二甲胺四环素组的77.08%（P<0.05）。联合组患者不良反应率为6.25%,显著低于二甲胺四环素组的20.83%（P<0.05）。结论二甲胺四环素联合茶多酚治疗早期种植体周围软组织炎效果显著,能够改善患者的临床症状,降低IL-1β、IL-17F水平,降低不良反应发生率。

关键词: 二甲胺四环素, 茶多酚, 种植体周围炎, 白细胞介素1β, 白细胞介素17F

Abstract: PURPOSE: To study the effect of dimethylamine tetracycline combined with tea polyphenols on the levels of interleukin-1 β (IL-1β) and interleukin-17F (IL-17F) in patients with early peri-implant soft tissue inflammation. METHODS: Ninety-six patients with early peri-implant soft tissue inflammation were selected from May 2016 to May 2018. They were randomly divided into dimethylamine tetracycline group and combination group, 48 cases in each group. Patients in the dimethylamine tetracycline group were treated with dimethylamine tetracycline hydrochloride ointment, while patients in the combined group were treated with tea polyphenols on the basis of dimethylamine tetracycline group. Plaque index (PLI), sulcus bleeding index (SBI), attachment loss (AL), gingival crevicular fluid (GCF), probing depth (PD), IL-1β and IL-17F levels were detected. The data were analyzed using SPSS 20.0 software package. RESULTS: After treatment, PLI, SBI, AL, GCF and PD in both groups were significantly lower than those before treatment (P<0.05). The levels of PLI, SBI, AL, GCF and PD in the combined group were significantly lower than those in the dimethylamine tetracycline group after treatment (P<0.05). After treatment, the levels of IL-1beta and IL-17F in both groups were significantly lower than those before treatment (P<0.05). After treatment, the levels of IL-1β and IL-17F in the combined group were significantly lower than those in the dimethylamine tetracycline group (P<0.05). The effective rate of combined group was 93.75%, which was significantly higher than that of dimethylamine tetracycline group (77.08%, P<0.05). The adverse reaction rate of the combined group was 6.25% ,significantly lower than that of the dimethylamine tetracycline group (20.83%, P<0.05). CONCLUSIONS: Dimethylamine tetracycline combined with tea polyphenols in the treatment of early peri-implant soft tissue inflammation has significant effect. It can improve the clinical symptoms of patients, reduce the levels of IL-1β and IL-17F, and decrease the occurrence of adverse effects.

Key words: Dimethylamine tetracycline, Tea polyphenols, Periimplantitis, Interleukin-1β, Interleukin-17F

中图分类号:

R781.4

李宇崚, 王卫忠, 龚忠诚. 二甲胺四环素联合茶多酚对早期种植体周围软组织炎患者IL-1β、IL-17F水平的影响[J]. 上海口腔医学, 2019, 28(5): 494-498.

LI Yu-leng, WANG Wei-zhong, GONG Zhong-cheng. Effects of dimethylamine tetracycline combined with tea polyphenols on the levels of IL-1β and IL-17F in patients with early peri-implant soft tissue inflammation[J]. Shanghai Journal of Stomatology, 2019, 28(5): 494-498.

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二甲胺四环素联合茶多酚对早期种植体周围软组织炎患者IL-1β、IL-17F水平的影响

Effects of dimethylamine tetracycline combined with tea polyphenols on the levels of IL-1β and IL-17F in patients with early peri-implant soft tissue inflammation

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