酪蛋白磷酸肽-无定形磷酸钙对正畸术后釉质再矿化的效果评价

doi:10.19439/j.sjos.2018.04.009

上海口腔医学 ›› 2018, Vol. 27 ›› Issue (4): 382-385.doi: 10.19439/j.sjos.2018.04.009

酪蛋白磷酸肽-无定形磷酸钙对正畸术后釉质再矿化的效果评价

王艳红¹, 刘帆¹, 刘浩男², 王秋旭², 邢文忠¹, 李振春¹

1.大连医科大学附属大连市口腔医院口腔科, 辽宁大连 116021;
2.中国医科大学附属盛京医院口腔颌面外科, 辽宁沈阳 110004

收稿日期:2018-03-22 修回日期:2018-05-28 出版日期:2018-08-25 发布日期:2018-10-09
通讯作者: 李振春,E-mail:yantu2007@163.com
作者简介:王艳红（1982-）,女,硕士,主治医师,E-mail: wangyanhong_603@163.com
基金资助:
大连市属卫生计生机构局级基金项目（WSJ/KJC-2015-JL-72）

Impact assessment on enamel remineralization after orthodontic treatment with casein phosphopeptide calcium phosphate complex

WANG Yan-hong¹, LIU Fan¹, LIU Hao-nan², WANG Qiu-xu², XING Wen-zhong¹, LI Zhen-chun¹

1.Department of Prosthodontics, Dalian Stomatological Hospital, Affiliated Stomatological Hospital of Dalian Medical University. Dalian 116021;
2.Department of Oral and Maxillofacial Surgery, Shengjing Hospital of China Medical University. Shenyang 110004, Liaoning Province, China

Received:2018-03-22 Revised:2018-05-28 Online:2018-08-25 Published:2018-10-09

摘要/Abstract

摘要： 目的: 比较含氟漱口水、护牙素即酪蛋白磷酸肽-无定形磷酸钙（casein phosphopeptide calcium phosphate complex,CPP-ACP）对正畸治疗后发生釉质脱矿的再矿化效果。方法: 应用Image J图像分析技术观察正畸治疗后釉质的再矿化。将固定矫治器正畸治疗后发生牙釉质脱矿的21例患者（女13例,男8例,84颗患牙）分为3组,每组28颗患牙。对照组仅用含氟牙膏每天刷牙2次,每次3 min。氟化物组用含氟牙膏每天刷牙2次,每次3 min,同时使用20 mL 0.01%氟化物冲洗牙2次。CPP-ACP组用含氟牙膏每天刷牙2次,每次3 min。同时按要求使用CPP-ACP 2次,3组均持续使用6个月。采用SPSS17.0软件包对数据进行统计学分析。结果: 正畸治疗后6个月,3组牙釉质脱矿白斑区域面积均有不同程度减少,3组治疗前、后均有显著差异（P<0.05）。CPP-ACP组效果尤为明显（51.68%）,显著高于氟化物组（44.42%）和对照组（42.71%）。结论: 正畸治疗后6个月内,正确刷牙、氟化物漱口、配合护牙素的使用,对正畸治疗中脱矿牙的再矿化均有一定效果, 而且CPP-ACP可以更有效地减小牙釉质脱矿白斑区域面积。

关键词: 酪蛋白磷酸肽-无定形磷酸钙, 正畸治疗, 釉质脱矿, 再矿化

Abstract: PURPOSE: To compare the effect on enamel demineralization following fluoride rinse or casein phosphopeptide calcium phosphate complex (CPP-ACP) after fixed appliance orthodontic treatment. METHODS: The study population consisted of 21 post-orthodontic patients (13 females, 8 males, 84 affected teeth) with white spot lesions (WSL). They were divided into 3 groups with 28 affected teeth in each group. Participants in the control group were brushed with fluoride toothpaste twice a day. Participants in the fluoride group were instructed to rinse the mouth with 20mL 0.01% sodium fluoride rinse in addition to brushing twice a day. Participants in CPP-ACP group were instructed to use tooth moss after brushing their teeth twice a day for 6 months. SPSS 17.0 software package was used to analyze the data. RESULTS: Within 6 months after orthodontic treatment, white spot lesions areas of the three groups caused by enamel demineralization were all reduced in different degrees, and the differences of success rate were significant among three groups (P<0.05). CPP-ACP group achieved the highest success rate (51%) than the other group, the fluoride group (44%) and the control group (42%). CONCLUSIONS: Brushing teeth, fluoride rinse and CPP-ACP have certain effect on remineralization of demineralized teeth in 6 months after orthodontic treatment. Compared with brushing and fluoride rinse, CPP-ACP can reduce the area of enamel demineralization more effectively.

Key words: Casein phosphopeptide-amorphous calcium phosphate, Orthodontic treatment, Enamel demineralization, Remineralization

中图分类号:

R783.5

王艳红, 刘帆, 刘浩男, 王秋旭, 邢文忠, 李振春. 酪蛋白磷酸肽-无定形磷酸钙对正畸术后釉质再矿化的效果评价[J]. 上海口腔医学, 2018, 27(4): 382-385.

WANG Yan-hong, LIU Fan, LIU Hao-nan, WANG Qiu-xu, XING Wen-zhong, LI Zhen-chun. Impact assessment on enamel remineralization after orthodontic treatment with casein phosphopeptide calcium phosphate complex[J]. Shanghai Journal of Stomatology, 2018, 27(4): 382-385.

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酪蛋白磷酸肽-无定形磷酸钙对正畸术后釉质再矿化的效果评价

Impact assessment on enamel remineralization after orthodontic treatment with casein phosphopeptide calcium phosphate complex

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