上海口腔医学

上海口腔医学 ›› 2014, Vol. 23 ›› Issue (1): 26-29.

• 基础研究 • 上一篇    下一篇

咬合创伤导致大鼠睡眠时的脑电图变化

孟春秀1, 2, 刘迪1, 赵晓1, 王诗沁1, 曹建波1, 汲平1   

  1. 1.山东大学口腔医院 修复科, 山东省口腔生物医学重点实验室, 山东 济南 250012;
    2.山东省聊城市人民医院 口腔科, 山东 聊城 252000
  • 收稿日期:2013-04-28 修回日期:2013-06-19 出版日期:2014-02-20 发布日期:2014-10-21
  • 通讯作者: 汲平,E-mail: jiping@sdu.edu.cn
  • 作者简介:孟春秀(1987-),E-mail: mengchunxiu153@163.com
  • 基金资助:
    山东大学自主创新基金(2010GN048)

Study on EEG changes after occlusal trauma during sleep in rats

MENG Chun-xiu1, 2, LIU Di1, ZHAO Xiao1, WANG Shi-qin1, CAO Jian-bo1, JI Ping1   

  1. 1.Department of Prosthodontics, College of Stomatology, Shandong University, Shandong Provincial Key Laboratory of Oral Biomedicine. Jinan 250012;
    2.Department of Stomatology, Liaocheng People’s Hospital. Liaocheng 252000, Shandong Province, China
  • Received:2013-04-28 Revised:2013-06-19 Online:2014-02-20 Published:2014-10-21
  • Supported by:
    Innovation Fund of Shandong University (2010GN048)

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摘要： 目的：探讨咬合创伤导致大鼠睡眠状态下的脑电图变化。方法：建立1、3、7、14和28 d组大鼠咬合创伤模型,于各截止时间麻醉大鼠,在脑立体定位仪的指导下,插入海马电极,记录睡眠状态下大鼠左右侧海马的脑电图(EEG)。采用SPSS17.0软件包对数据进行单因素方差分析。结果：咬合创伤1 d组大鼠δ波指数增加,脑电频率及波幅降低(P<0.05);3 d组大鼠δ波指数降低,频率和波幅增加,与对照组相比,差异均无显著性;7 d组、14 d组大鼠δ波指数降低,脑电频率及波幅增加(P<0.05);28 d组各项指标趋于正常。结论：咬合创伤可改变大鼠的睡眠脑电活动,主要影响大鼠的深度睡眠,降低大鼠的睡眠质量。

关键词: 咬合创伤, 海马, 脑电图

Abstract: PURPOSE: To explore the electroencephalogram (EEG) changes after occlusal trauma in rats. METHODS: Health Wistar rats were divided into 2 groups: traumatic occlusion group (1-day, 3-day, 7-day, 14-day, 28-day group) and control group. The electrodes were inserted in the hippocampus of anesthetized rats guided by stereotaxic apparatus of brain and then the hippocampal EEG were recorded during sleep. Data were analysed by SPSS 17.0 software package for ANOVA. RESULTS: The δ waves were increased and the frequency and amplitude of EEG were significantly reduced in 1-day traumatic group(P<0.05); The waves were decreased and the frequency and amplitude of EEG were significantly increased in 3-day traumatic group(P<0.05). There was no significant difference compared with the control group. The δ waves were decreased in 7-day and 14-day traumatic group and the frequency and amplitude of EEG were significantly increased (P<0.05). The indexes in the 28-day traumatic group returned to normal. CONCLUSIONS: Occlusal trauma can change the EEG of the rat during sleep. It mainly affects the deep sleep, and reduces sleep quality.

Key words: Occlusal trauma, Hippocampus, Electroencephalogram

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