垂体瘤转化基因在唾液腺腺样囊性癌侵袭转移中的作用

上海口腔医学 ›› 2013, Vol. 22 ›› Issue (6): 667-670.

垂体瘤转化基因在唾液腺腺样囊性癌侵袭转移中的作用

戚忠政¹，刘洁²，刘法昱¹，孙长伏¹

(1.中国医科大学口腔医学院辽宁省口腔医学研究所口腔颌面外科，辽宁沈阳 110002；2.中国医科大学中心实验室，辽宁沈阳 110001)

收稿日期:2013-07-04 修回日期:2013-08-22 出版日期:2013-04-12 发布日期:2013-04-12
通讯作者: 孙长伏，Tel：024-22894773，E-mail:changfusun@hotmail.com
作者简介:戚忠政(1978-)，男，博士，主治医师，E-mail：daqi00001@sina.com
基金资助:
国家自然科学基金青年基金(81102058)

Effect of pituitary tumour transforming gene on invasion and metastasis of salivary adenoid cystic carcinoma

QI Zhong-zheng¹, LIU Jie², LIU Fa-yu¹, SUN Chang-fu¹

1.Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University. Shenyang 110002; 2.Department of Central Laboratory, China Medical University. Shenyang 110001, Liaoning Province, China

Received:2013-07-04 Revised:2013-08-22 Online:2013-04-12 Published:2013-04-12
Supported by:
Supported by National Natural Science Foundation of China(81102058).

摘要/Abstract

摘要： 目的：研究垂体瘤转化基因(PTTG)的表达在唾液腺腺样囊性癌(SACC)侵袭和转移中的作用。方法：应用免疫组织化学SP法检测40例SACC组织及20例癌旁正常组织中PTTG和碱性成纤维细胞生长因子(bFGF)的表达。采用SPSS11.5软件包，应用χ²检验和Spearman相关性分析进行统计学处理。结果：SACC组织中PTTG和bFGF的蛋白表达显著高于癌旁正常组织(P均<0.01)；PTTG与bFGF的蛋白表达水平呈正相关(P<0.01)。结论：PTTG与bFGF在SACC组织中高表达，PTTG的表达与SACC的侵袭和转移密切相关。

关键词: 垂体瘤转化基因, 唾液腺腺样囊性癌, 免疫组织化学

Abstract: PURPOSE: To study the effect of pituitary tumour transforming gene (PTTG) on invasion and metastasis of salivary adenoid cystic carcinoma. METHODS: The expression of PTTG and bFGF was investigated in 40 salivary adenoid cystic carcinoma tissues and 20 normal salivary tissues by immunohistochemistry. Pearson’s Chi-square test and Spearman correlation analysis were used to analyze the data using SPSS 11.5 software package. RESULTS: The expression of PTTG and bFGF were significantly higher in salivary adenoid cystic carcinoma tissues than in normal salivary gland tissues(P<0.01)and their expression levels were positively correlated(P<0.01). CONCLUSIONS: PTTG and bFGF are highly expressed in salivary adenoid cystic carcinoma. The invasion and metastasis of salivary adenoid cystic carcinoma are correlated with the expression of PTTG.

Key words: Pituitary tumor transforming gene, Salivary adenoid cystic carcinoma, Immunohistochemistry

中图分类号:

R739.87

戚忠政, 刘洁, 刘法昱, 孙长伏. 垂体瘤转化基因在唾液腺腺样囊性癌侵袭转移中的作用[J]. 上海口腔医学, 2013, 22(6): 667-670.

QI Zhong-zheng, LIU Jie, LIU Fa-yu, SUN Chang-fu. Effect of pituitary tumour transforming gene on invasion and metastasis of salivary adenoid cystic carcinoma[J]. Shanghai Journal of Stomatology, 2013, 22(6): 667-670.

参考文献

[1] 芦杨, 齐鸿亮. MMP-2和MVD在腺样囊性癌中的表达及临床意义 [J]. 中国实用口腔科杂志, 2009, 2(7): 415-417.
[2] Vlotides G, Eigler T, Melmed S. Pituitary tumor-transforming gene: physiology and implications for tumorigenesis [J]. Endocr Rev, 2007, 28(2): 165-186.
[3] Salehi F, Kovacs K, Scheithauer BW, et al. Pituitary tumor-transforming gene in endocrine and other neoplasms: a review and update [J]. Endocr Relat Cancer, 2008, 15(3): 721-743.
[4] Yan S, Zhou C, Lou X, et al. PTTG overexpression promotes lymph node metastasis in human esophageal squamous cell carcinoma [J]. Cancer Res, 2009, 69(8): 3283-3290.
[5] Tas F, Duranyildiz D, Oguz H, et al. Circulating serum levels of angiogenic factors and vascular endothelial growth factor receptors-1 and 2 in melanoma patients [J]. Melanoma Res, 2006, 16(5): 405-411.
[6] Minematsu T, Suzuki M, Sanno N, et al. PTTG overexpression is correlated with angiogenesis in human pituitary adenomas [J]. Endocr Pathol, 2006, 17(2): 143-153.
[7] Hunter JA, Skelly RH, Aylwin SJ, et al. The relationship between pituitary tumour transforming gene (PTTG) expression and in vitro hormone and vascular endothelial growth factor (VEGF) secretion from human pituitary adenomas[J]. Eur J Endocrinol,2003,148(2): 203-211.
[8] Ishikawa H, Heaney AP, Yu R, et al. Human pituitary tumor-transforming gene (PTTG) induces angiogenesis [J]. J Clin Endocrinol Metab, 2001, 86(2): 867-874.
[9] Okada-Ban M, Thiery JP, Jouanneau J. Fibroblast growth factor-2 [J]. Int J Biochem Cell Biol, 2000, 32(3): 263-267.
[10] Torimura T, Ueno T, Kin M, et al. Autocrine motility factor enhances hepatoma cell invasion across the basement membrane through activation of β1 integrins [J]. Hepatology, 2001, 34(1): 62-71.
[11] Kim DS, Franklyn JA, Stratford AL, et al. Pituitary tumor transforming gene regulates multiple downstream angiogenic genes in thyroid cancer [J]. J Clin Endocrinol Metab, 2006, 91(3): 1119-1128.
[12] McCabe CJ, Boelaert K, Tannahill LA, et al. Vascular endothelial growth factor, its receptor KDR/Flk21, and pituitary tumor transforming gene in pituitary tumors [J]. J Clin Endocrinol Metab, 2002, 87(9): 4238-4244.