上海口腔医学

上海口腔医学 ›› 2025, Vol. 34 ›› Issue (6): 651-655.doi: 10.19439/j.sjos.2025.06.017

• 论著 • 上一篇    下一篇

西帕依固龈液联合甲硝唑治疗种植体周围炎的疗效及对龈沟液MMP-8、NO水平的影响

刘伟东, 江银华, 胡勤妮, 徐航   

  1. 丽水市人民医院 口腔科, 浙江 丽水 323000
  • 收稿日期:2024-07-23 修回日期:2024-08-27 发布日期:2025-12-30
  • 通讯作者: 刘伟东,E-mail：luomeisx@126.com
  • 作者简介:刘伟东（1974-）,男,本科,主任医师
  • 基金资助:
    丽水市科技项目（2020SJZC026）

Therapeutic effect of Xipayi Guyin fluid combined with metronidazole in treating periimplantitis and its impact on MMP-8 and NO levels in gingival crevicular fluid

Liu Weidong, Jiang Yinhua, Hu Qinni, Xu Hang   

  1. Department of Stomatology, Lishui People's Hospital. Lishui 323000, Zhejiang Province, China
  • Received:2024-07-23 Revised:2024-08-27 Published:2025-12-30

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摘要： 目的:探讨西帕依固龈液联合甲硝唑治疗种植体周围炎的疗效及对龈沟液基质金属蛋白酶8（matrix metalloproteinase 8,MMP-8）水平和一氧化氮（NO）水平的影响。方法:选择2021年1月—2024年1月于丽水市人民医院治疗的种植体周围炎患者84例,分为试验组和对照组,每组各42例。对照组单独采用甲硝唑治疗,试验组在服用甲硝唑的基础上联用西帕依固龈液漱口。比较治疗前后两组患者龈沟液中白细胞介素6（interleukin 6,IL-6）、MMP-8和转化生长因子α（transforming growth factor α,TGF-α）及NO水平,依照菌斑指数（plaque index,PLI）和龈沟出血指数（sulcus bleeding index,SBI）对患者的菌斑数量和出血程度进行分析,判断患者治疗结束后的临床总有效率及不良反应发生率。结果:试验组临床总有效率为73.81%,显著高于对照组的52.38%（P<0.05）;治疗后2组患者的PLI、SBI、NO、IL-6、MMP-8、TGF-α水平与治疗前相比显著降低,且试验组显著低于对照组（P<0.05）。试验组和对照组的不良反应发生率分别为2.38%和7.14%,组间差异无显著性（P>0.05）。结论:西帕依固龈液联合甲硝唑有助于抑制口腔病原微生物增殖,降低MPP-8等炎症因子水平和调节NO水平,健齿固龈,对种植体周围炎有很好的控制作用。

关键词: 种植体周围炎, 西帕依固龈液, 甲硝唑, 基质金属蛋白酶8, 一氧化氮

Abstract: PURPOSE: To investigate the therapeutic effect of Xipayi Guyin fluid combined with metronidazole in treating periimplantitis and its impact on the levels of matrix metalloproteinase 8 (MMP-8) and nitric oxide (NO) in gingival crevicular fluid. METHODS: A total of 84 patients with periimplantitis treated in Lishui People's Hospital from January 2021 to January 2024 were selected and divided into experimental group and control group, with 42 patients in each group. The control group was treated with metronidazole alone, while the experimental group was treated with Xipayi Guyin fluid on the basis of metronidazole. The levels of interleukin 6(IL-6), MMP-8, transforming growth factor α(TGF-α), and NO were compared between the two groups before and after treatment, and the number of plaques and degree of bleeding in patients were analyzed based on the plaque index(PLI) and sulcus bleeding index (SBI), and the clinical total effective rate and incidence of adverse reactions after treatment were observed. RESULTS: The total clinical effective rate of the experimental group was 73.81%, which was significantly higher than that of the control group(52.38%)(P<0.05). After treatment, the PLI, SBI, NO, IL-6, MMP-8 and TGF-α level of the two groups were obviously reduced compared to pre-treatment, and there was significant difference between the two groups(P<0.05). The adverse reaction ratio of the experimental group and the control group were 2.38% and 7.14%, respectively, with no significant difference between the two groups (P>0.05). CONCLUSIONS: The combination of Xipayi Guyin fluid and metronidazole can help inhibit the proliferation of oral pathogenic microorganisms, reduce the levels of inflammatory factors such as MPP-8 and regulate NO level. It also helps to strengthen teeth and gums, with controlling effect on the onset of periimplantitis in patients.

Key words: Periimplantitis, Xipayi Guyin fluid, Metronidazole, Matrix metalloproteinase-8, Nitric oxide

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