上海口腔医学

上海口腔医学 ›› 2022, Vol. 31 ›› Issue (5): 471-475.doi: 10.19439/j.sjos.2022.05.005

• 论著 • 上一篇    下一篇

负载氯己定的埃洛石纳米管对牙本质粘结强度的影响

谢惠兰1, 陈江2, 曹白雨1, 林毅1   

  1. 1.福建省立医院 口腔科,福建 福州 350001;
    2.福建医科大学附属口腔医学院,福建省口腔生物材料工程技术研究中心,福建 福州 350004
  • 收稿日期:2021-04-15 修回日期:2021-07-15 出版日期:2022-10-25 发布日期:2022-11-01
  • 通讯作者: 陈江, E-mail: dentistjiangch@sina.com
  • 作者简介:谢惠兰(1982-),女,硕士研究生,副主任医师,E-mail:xhl-0505@163.com
  • 基金资助:
    福建省口腔生物材料工程技术研究中心开放课题（2019kq004）

Effect of chlorhexidine-loaded halloysite nanotube on human dentin bond strength

XIE Hui-lan1, CHEN Jiang2, CAO Bai-yu1, LIN Yi1   

  1. 1. Department of Stomatology, Fujian Provincial Hospital. Fuzhou 350001;
    2. School and Hospital of Stomatology, Fujian Medical University; Fujian Biological Materials Engineering and Technology Center of Stomatology. Fuzhou 350004, Fujian Province, China
  • Received:2021-04-15 Revised:2021-07-15 Online:2022-10-25 Published:2022-11-01

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摘要： 目的: 探讨将负载氯己定的埃洛石纳米管掺入全酸蚀粘接剂ONE-STEP及自酸蚀粘接剂XENO Ⅴ后对牙本质粘结强度的影响。方法: 将120颗离体牙分为10组,根据粘接剂XE、OS以及掺入负载氯己定（chlorhexidine,CHX）的埃洛石纳米管（halloysite nanotube,HNT）质量体积比5%、10%、15%分组, 分别为XE对照组（A1组）、XE实验对照组（A2组）、5%CHX/HNT-XE组（A3组）、10%CHX/HNT-XE组（A4组）、15%CHX/HNT-XE组（A5组）、OS对照组（B1组）、OS实验对照组（B2组）、5%CHX/HNT-OS组（B3组）、10%CHX/HNT-OS组（B4组）和15%CHX/HNT-OS组（B5组）。树脂充填24 h后,测试拉伸剪切强度（tensile shear strength,TSS）值。电镜扫描,观察粘结界面嵌合层的形态。采用SPSS 19.0软件包对同一粘接剂各组以单因素方差分析TSS值,不同粘接剂及不同质量比各组以双因素方差分析TSS值。结果: 自酸蚀XE多组中,5%CHX/HNT组的TSS值最高;全酸蚀OS组中,10%CHX/HNT组的TSS值最高（P<0.05）。不同品牌粘接剂对TSS无显著影响,而CHX/HNT质量体积比对TSS有显著影响。结论: 将适合浓度的CHX/HNT掺入自酸蚀粘接剂XENO Ⅴ和全酸蚀粘接剂ONE-STEP中,可增加牙本质粘结强度。

关键词: 埃洛石纳米管, 氯己定, 牙本质, 拉伸剪切强度, 嵌合层

Abstract: PURPOSE: To evaluate the effect of chlorhexidine-loaded halloysite aluminosilicate clay nanotube (HNT) incorporation into a two-step etch-and-rinse (ONE-STEP) and a self-etch (XENO Ⅴ) adhesive on human dentin tensile shear strength (TSS). METHODS: Ten groups (n=12) were prepared according to the adhesive system and amount of CHX/HNT incorporated (5%, 10%, 15%) as follows: XE control(A1), XE experimental control (A2), 5% CHX/HNT-XE (A3), 10%CHX/HNT-XE (A4), 15% CHX/HNT-XE (A5), OS control (B1), OS experimental control (B2), 5% CHX/HNT-OS (B3), 10% CHX/HNT-OS (B4), 15% CHX/HNT-OS (B5). TSS testing was performed after 24 h. Scanning electron microscopy of the resin-dentin interface of selected specimens was carried out. One-way ANOVA was used to evaluate the TSS date in XE groups and OS groups. Two-way ANOVA was used to evaluate the effect of the adhesive system and the CHX/HNT content on dentin TSS with SPSS 19.0 software package. RESULTS: The TSS date of 5% CHX/HNT-XE was significantly higher than the other groups. The TSS date of 10% CHX/HNT-OS was significantly higher than the other groups (P<0.05). No significant difference was detected between adhesive systems and dentin TSS. significant difference was found between CHX/HNT content and dentin TSS. CONCLUSIONS: CHX/HNT addition into dentin adhesive increased bond strength to dentin.

Key words: Halloysite nanotube, Chlorhexidine, Dentin, Tensile shear strength, Hybrid layer

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