Comparison of the effect of A-PRF and CGF on the recovery of mandibular impacted third molar after extraction and on alveolar ridge of the adjacent second molar

doi:10.19439/j.sjos.2025.01.017

Abstract

Abstract: PURPOSE: To compare the recovery effect of advanced platelet-rich fibrin (A-PRF) and concentrated growth factor (CGF) in the treatment of mandibular impacted third molar(M3) extraction, and the effect on alveolar ridge of the adjacent second molar(M2). METHODS: A total of 150 patients who received mandibular impacted M3 extraction in Jinhua Central Hospital from September 2020 to August 2021 were included. Among them, group A (n=49) received conventional suture, group B (n=51)received conventional suture +A-PRF filling, and group C(n=50) received conventional suture +CGF filling. Postoperative clinical indexes, soft tissue healing, alveolar bone density changes and M2 alveolar ridge height changes were compared among the three groups. Meanwhile, complications and adverse reactions were recorded and compared among the three groups. SPSS 20.0 software package was used for data analysis. RESULTS: One week after surgery, the pain degree and swelling degree of the three groups were lower than before treatment(P<0.05), and group B < group C < group A(P<0.05). Mouth opening degree was higher than before treatment(P<0.05), group B > group C > group A (P<0.05), and the soft tissue healing condition of group B was better than that of group C, and than that of group A(P<0.05). At 6 weeks and 12 weeks after surgery, the alveolar bone mineral density of the three groups was higher than that immediately after surgery(P<0.05), and group B > group C > group A(P<0.05). There were significant differences between group B and C at 6 weeks and 12 weeks after surgery (P<0.05). The M2 alveolar ridge height (ΔH) 12 days after surgery was lower than that immediately after surgery(P<0.05), and group B and C was lower than that of group A (P<0.05). The incidence of complications such as bleeding, infection, dry socket, nerve injury and periodontal pus discharge in group B < group C < group A, and the incidence of complications was statistically significant(P<0.05). CONCLUSIONS: The effects of A-PRF and CGF on M2 alveolar ridge and postoperative adverse reactions are similar, but A-PRF is better than CGF in improving clinical symptoms and promoting postoperative recovery in maxillary impacted M3 patients, with fewer complications, and is worthy of clinical promotion.

Key words: Advanced platelet-rich fibrin, Concentrated growth factor, Extraction of mandibular impacted third molar, Distal second molar alveolar crest height

CLC Number:

R782.1

PU Li-li, CHEN Chun-hui, TONG Xi. Comparison of the effect of A-PRF and CGF on the recovery of mandibular impacted third molar after extraction and on alveolar ridge of the adjacent second molar[J]. Shanghai Journal of Stomatology, 2025, 34(1): 94-99.

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