Abstract: PURPOSE: To detect the expression and significance of Ki-67, PI3K and Beclin1 in oral squamous cell carcinoma (OSCC). METHODS: Thirty patients with OSCC admitted to Nanjing Stomatology Hospital from January 2017 to December 2018 were selected. All specimens were harvested and treated with immunohistochemical staining. The expressions of Ki-67, PI3K and Beclin 1 were detected. Pearson's correlation was used to analyze the correlation among TMSG-1, Ki-67 and Pgp1.The data were analyzed with SPSS 20.0 software package. RESULTS: The positive rates of Ki-67 and PI3K in OSCC tissues were significantly higher than those in adjacent tissues, and the positive rates of Beclin1 were significantly lower than those in adjacent tissues (P<; 0.05). The positive expression rates of Ki-67, PI3K and Beclin1 in highly differentiated OSCC were significantly higher than those in moderately differentiated and poorly differentiated OSCC (P<; 0.05). The positive expression rates of Ki-67 and PI3K in OSCC with lymph node metastasis were significantly higher than those in OSCC without lymph node metastasis. The positive expression rates of Beclin1 in OSCC with lymph node metastasis were significantly lower than those in OSCC without lymph node metastasis (P<; 0.05). The positive expression rates of Ki-67, PI3K and Beclin1 in stageⅠ+Ⅱ and Ⅲ+Ⅳ OSCC were not significantly different (P>; 0.05). Ki-67 was positively correlated with PI3K (r=0.391, P=0.032), Ki-67 was negatively correlated with Beclin1 (r=-0.525, P=0.02), and Beclin1 was negatively correlated with PI3K(r=-0.367, P=0.045). CONCLUSIONS: Ki-67, PI3K and Beclin1 are correlated with lymph node metastasis and pathological staging. They may be involved in the occurrence and development of OSCC.

Key words: Oral squamous cell carcinoma, Ki-67, Phosphoinositol-3-kinase, Beclin1