The diagnosis and treatment of arsenic trioxide induced necrosis of jaws: report of 10 consecutive cases

Shanghai Journal of Stomatology ›› 2014, Vol. 23 ›› Issue (6): 755-758.

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The diagnosis and treatment of arsenic trioxide induced necrosis of jaws: report of 10 consecutive cases

WU Ye, LIN Li-song, NIU Gang, XIE Fu-ping

Department of Oral and Maxillofacial Surgery, The Affiliated Stomatological Hospital of Fujian Medical University. Fuzhou 350002, Fujian Province, China

Received:2014-08-06 Revised:2014-09-29 Online:2014-12-20 Published:2015-01-08
Supported by:
Preferential Funding Overseas Personnel Activities in Science and Technology Project of Ministry of Human Resources and Social Security of China (2009), Natural Science Foundation of Fujian Province(2014J01316) and Foundation of Department of Education of Fujian Province（JA11125）

Abstract

Abstract: PURPOSE: To discuss the diagnosis and treatment of necrosis of jaws caused by leakage of arsenite trioxide, and to emphasize the consequences of its use. METHODS: Ten cases of arsenical necrosis of the jaws from Jan, 2009 to Jun, 2014 treated in our department were collected and analyzed, with emphasis on the key points of diagnosis and treatment. RESULTS: Diagnosis was based on medical history, clinical examinations, X-ray findings, and preoperative or intraoperative cone-beam CT (CBCT) scans. Nine patients were cured with primary operation, one patient was cured by secondary extended surgery. CONCLUSIONS: Because of the high toxicity, there is no justification for the use of arsenite trioxide in clinic.

Key words: Arsenic trioxide, Necrosis of jaws, Iatrogenic injury

CLC Number:

R782.4

WU Ye, LIN Li-song, NIU Gang, XIE Fu-ping. The diagnosis and treatment of arsenic trioxide induced necrosis of jaws: report of 10 consecutive cases[J]. Shanghai Journal of Stomatology, 2014, 23(6): 755-758.

References

[1] Yavuz MS, Kaya GS, Yalçin E, et al. Mandibular bone necrosis caused by use of arsenic paste during endodontic treatment: two case reports [J]. Int Endod J, 2008, 41(7): 633-637.
[2] Ozmeriç N. Localized alveolar bone necrosis following the use of an arsenical paste: a case report[J]. Int Endod J,2002,35(3):295-299.
[3] Chen G, Sung PT. Gingival and localized alveolar bone necrosis related to the use of arsenic trioxide paste-two case reports [J]. J Formos Med Assoc, 2014, 113(3): 187-190.
[4] Yalçin S, Aybar B, Haznedarolu F, et al. Bilateral oroantral fistulas following devitalization of teeth by arsenic trioxide: a case report [J]. J Endod, 2003, 29(3): 205-207.
[5] 郑麟蕃, 张震康, 俞光岩.实用口腔科学 [M]. 第2版. 北京:人民卫生出版社, 1999: 278-279.
[6] 高子龙, 吕娟, 李金超, 等. 瓷冠修复后砷剂致上颌骨骨髓炎1例并文献复习 [J]. 现代口腔医学杂志, 2012, 26(2): 135-136.
[7] 王鑫, 汪学华, 陆钰, 等. 锥形束CT在儿童上颌前部埋伏多生牙定位中的应用 [J]. 安徽医学, 2011, 32(10): 1701-1703.
[8] 张志愿. 口腔颌面外科学[M]. 第7版. 北京: 人民卫生出版社, 2012: 210.
[9] Solomon DH, Mercer E, Woo SB, et al. Defining the epidemiology of bisphosphonate-associated osteonecrosis of the jaw: prior work and current challenges [J]. Osteoporos Int, 2013, 24(1): 237-244.
[10] 盛璐, 文建民, 童昕. 双磷酸盐相关性颌骨坏死1例报道及文献复习 [J]. 广东牙病防治, 2013, 21(12): 660-662.
[11] 王效平, 王忠桂, 王小婷, 等. 后磨牙牙髓疼痛3 种止痛方法的效果比较 [J]. 上海口腔医学, 2004, 13(2): 147-149.
[12] Dumlu A, Yalcinkaya S, Olgac V, et al. Osteomyelitis due to arsenic trioxide use for tooth devitalization [J]. Int Endod J, 2007, 40(4): 317-322.

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The diagnosis and treatment of arsenic trioxide induced necrosis of jaws: report of 10 consecutive cases

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