Relationship between DEK oncogene expression and oral squamous cell carcinoma

Abstract

Abstract: PURPOSE: To investigate the expression of gene DEK in oral squamous cell carcinoma, and explore the role of DEK in the development and metastasis of oral squamous cell carcinoma. METHODS: Thirty-three specimens of oral squamous cell carcinoma (OSCC), 28 specimens of cervical lymph nodes metastasis, and 33 specimens of normal oral mucosal tissues adjacent to the cancerous lesions were examined. Polymerase chain reaction with reverse transcription (RT - PCR) and immunohistochemistry were used to detect mRNA and protein expression of DEK, respectively.The results were analysed with SPSS17.0 software package. RESULTS: RT-PCR and immunohistochemistry showed that the expression of DEK mRNA and DEK protein in metastatic lymph nodes (82.1%, 82.1%) and cancerous tissues (81.2%, 76.8%) of OSCC were significantly higher than in the adjacent tissues (27.3%, 18.2%). The difference between cancerous tissues and adjacent tissues was significant (P<0.05). CONCLUSION: DEK may play an important role in the occurrence and metastasis of OSCC.

Key words: DEK, Oral squamous cell carcinoma, Cell apoptosis

CLC Number:

R739.8

WANG Xuan, HUANG Shao-hui, YU Li-qiao, LIU Jie, DIAO Yao, SUN Chang-fu. Relationship between DEK oncogene expression and oral squamous cell carcinoma[J]. Shanghai Journal of Stomatology, 2014, 23(1): 75-79.

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