bFGF雾化吸入对全麻下口腔颌面外科术后咽喉痛的疗效观察

上海口腔医学 ›› 2016, Vol. 25 ›› Issue (4): 497-499.

bFGF雾化吸入对全麻下口腔颌面外科术后咽喉痛的疗效观察

刘斌，江银华，肖健，李校堃

温州医科大学，浙江温州 325035

收稿日期:2015-06-24 出版日期:2016-08-25 发布日期:2016-09-06
通讯作者: 李校堃，E-mail：xjwmu2015@163.com
作者简介:刘斌（1976-），男，学士，主任医师，E-mail：doctorliubin@163.com
基金资助:
浙江省丽水市高层次人才培养资助项目(2014RC26)

Efficacy of bFGF atomization inhalation on postoperative sore throat following oral and maxillofacial surgery under general anesthesia

LIU Bin, JIANG Yin-hua, XIAO Jian, LI Xiao-kun

Wenzhou Medical University. Wenzhou 355035, Zhejiang Province, China

Received:2015-06-24 Online:2016-08-25 Published:2016-09-06

摘要/Abstract

摘要： 目的：观察重组人碱性成纤维细胞生长因子（bFGF）雾化吸入对全麻下口腔颌面外科术后咽喉痛的疗效。方法：将全麻下口腔颌面外科术后拔除气管导管的40例患者随机分为治疗组和对照组；治疗组给予bFGF 35000IU+生理盐水20 mL，压缩雾化吸入、每天1次，每次20 min，连续3 d；对照组给予生理盐水5 mL+地塞米松5 mg+庆大霉素8万U+糜蛋白酶4000 U，压缩雾化吸入、每天2次，每次20 min，连续3 d。分别记录2组术后12 h咽痛发生情况及咽痛(吞咽时)12 、24 、48 、72 h视觉模拟评分(VAS)，采用SPSSl4.0软件包对数据进行统计学分析。结果：治疗组术后12 h咽痛发生率显著低于对照组(P<0.01)；治疗组术后12、24、48 和72 h咽痛(吞咽时)VAS均显著低于对照组(P<0.05)。结论：bFGF雾化吸入能降低口腔颌面外科气管插管全麻术后咽痛发生率及咽痛程度。

关键词: 全麻, 术后咽喉痛, 气管插管

Abstract: PURPOSE: To observe the effect of recombinant human basic fibroblast growth factor (bFGF) atomization inhalation on postoperative sore throat following oral and maxillofacial operation under general anethesia. METHODS: Forty patients in whom oral and maxillofacial operation trachea was removed under general anesthesia were randomly divided into treatment and control groups; the treatment group received bFGF 35000IU + normal saline 20 mL, compression inhalation, day 1, every 20min, continued for 3 d; the control group was given normal saline 5 mL + dexamethasone 5 mg + gentamicin 80000 U + chymotrypsin 4000 U, compression inhalation, twice a day, every 20 min, continued for 3 d. Occurrence of postoperative sore throat 12 h after operation was recorded and visual analog scale (VAS) of sore throat (swallowing) 12,24,48,72 h after operation was measured. SPSS l4.0 software package was used for statistical analysis. RESULTS: The incidence of sore throat in the treatment group was significantly lower than that in the control group (P<0.01) 12 h after operation; sore throat (swallowing) VAS 12,24,48 and 72 h after operation in the treatment group were significantly lower than that in the control group (P<0.05). CONCLUSIONS: bFGF atomization inhalation can reduce the incidence of sore throat and sore throat level in oral and maxillofacial surgery after endotracheal intubation.

Key words: General anesthesia, Postoperative sore throat, Trachea cannula

中图分类号:

R780.1

刘斌，江银华，肖健，李校堃. bFGF雾化吸入对全麻下口腔颌面外科术后咽喉痛的疗效观察[J]. 上海口腔医学, 2016, 25(4): 497-499.

LIU Bin, JIANG Yin-hua, XIAO Jian, LI Xiao-kun. Efficacy of bFGF atomization inhalation on postoperative sore throat following oral and maxillofacial surgery under general anesthesia[J]. Shanghai Journal of Stomatology, 2016, 25(4): 497-499.

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