DNA定量分析在口腔癌及癌前病变中的研究进展

上海口腔医学 ›› 2015, Vol. 24 ›› Issue (1): 124-128.

• 综述 • 上一篇

DNA定量分析在口腔癌及癌前病变中的研究进展

肖璇,施琳俊,周曾同

上海交通大学医学院附属第九人民医院·口腔医学院口腔黏膜病科,上海市口腔医学重点实验室,上海 200011

收稿日期:2013-11-11 出版日期:2015-02-20 发布日期:2015-07-24
通讯作者: 周曾同,E-mail:zhouzengtong@hotmail.com
作者简介:肖璇（1986-）,女,在读博士研究生,E-mail:Princeton2009@163.com
基金资助:
上海市科学技术委员会科研基金（11DZ1972600）; 上海市卫生局基金（ZYSNXD-CC-ZDYJ004)

Research progress of quantitative DNA analysis in oral carcinoma and precancerous lesions

XIAO Xuan,SHI Lin-Jun,ZHOU Zeng-tong

Department of Oral Mucosal Diseases, Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine;Shanghai Key Laboratory of Stomatology. Shanghai 200011, China

Received:2013-11-11 Online:2015-02-20 Published:2015-07-24
Supported by:
Research Fund of Science and Technology Committee of Shanghai Municipality (11DZ1972600) and Research Fund of Bureau of Health of Shanghai Municipality (ZYSNXD-CC-ZDYJ004)

摘要/Abstract

摘要： 人体正常的体细胞有23对染色体,DNA含量恒定,在细胞癌变过程中DNA含量增加或减少,即成为非整倍体细胞,是恶性肿瘤的特异性标志。DNA定量分析是通过对细胞核内DNA含量或倍体的检测来判断细胞的生理或病理状态,能客观地反映病损的情况,对肿瘤的早期诊断、筛查、预后判断及疗效评价有重要意义。本文主要就近年来DNA定量分析在口腔癌及癌前病变中的研究进展作一综述。

关键词: DNA定量分析, DNA倍体, 口腔癌, 癌前病变

Abstract: Normal individual cells had 23 pairs of chromosome and stable DNA content. DNA content was varied during malignant transformation, which was specific feature of tumor. Quantitative DNA analysis can reflect cellular physiological or pathological condition by nuclear DNA content, which had significant role in early diagnosis, predication of prognosis and treatment selection. This article summarized the research progress of quantitative DNA analysis in oral carcinoma and precancerous lesions in recent years.

Key words: Quantitative DNA analysis, DNA ploidy, Oral carcinoma, Precancerous lesions

中图分类号:

R739.8

肖璇,施琳俊,周曾同. DNA定量分析在口腔癌及癌前病变中的研究进展[J]. 上海口腔医学, 2015, 24(1): 124-128.

XIAO Xuan,SHI Lin-Jun,ZHOU Zeng-tong. Research progress of quantitative DNA analysis in oral carcinoma and precancerous lesions[J]. Shanghai Journal of Stomatology, 2015, 24(1): 124-128.

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DNA定量分析在口腔癌及癌前病变中的研究进展

Research progress of quantitative DNA analysis in oral carcinoma and precancerous lesions

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