正畸治疗中牙龈蛋白K与牙龈炎性反应的关系

上海口腔医学 ›› 2015, Vol. 24 ›› Issue (1): 102-106.

正畸治疗中牙龈蛋白K与牙龈炎性反应的关系

杨刚岭¹,李伟哲²,韩志强^3,4,肖水清³

1.山东省滨州市人民医院口腔科,山东滨州 256603;
2.山东省荣成市石岛人民医院口腔科,山东威海 264309;
3.山东省济南市口腔医院正畸科,山东济南 250001;
4.山东省滨州医学院口腔学院正畸教研室,山东滨州 256603

出版日期:2015-02-20 发布日期:2015-07-24
通讯作者: 肖水清,E-mail:shqxiao@126.com
作者简介:杨刚岭（1966-）,男,主治医师,E-mail:826964972@qq.com
基金资助:
济南市科技局企业创新计划（201121038）

Detection of gingipain K in the gingival crevicular fluid of orthodontic patients

YANG Gang-ling¹,LI Wei-zhe²,HAN Zhi-qiang^3,4,XIAO Shui-qing³

1.Department of Stomatology, Binzhou People’s Hospital. Binzhou 256603;
2.Department of Stomatology, the People’s Hospital of Rongcheng. Rongcheng 264309;
3.Department of Orthodontics, Jinan Stomatological Hospital. Jinan 250001;
4.Department of Orthodontics, Hospital of Stomatology, Binzhou Medical University. Binzhou 256603, Shandong Province, China

Online:2015-02-20 Published:2015-07-24
Supported by:
Enterprise Innovation Plan of Science and Technology Bureau of Jinan City（201121038）

摘要/Abstract

摘要： 目的分析牙龈蛋白K（gingipain K,Kgp）在正畸治疗中对牙龈炎性反应的影响。方法选择青少年牙龈健康者45例,分别取矫治器戴入前与矫治器戴入后3个月的龈沟液,应用16S rDNA PCR技术检测各样本中的牙龈卟啉单胞菌（P.g）及Kgp,采用SPSS17.0软件包对数据进行统计学分析。结果矫治器戴入前Kgp检出率为35.71%,矫治器戴入后Kgp检出率为67.86%,两者之间差异显著（P<0.05）。结论正畸治疗患者在矫治器戴入后Kgp检出率增加,出现牙龈炎性反应。

关键词: 正畸治疗, 牙龈蛋白Kgp, 16S rDNA PCR技术, 牙龈炎

Abstract: PURPOSE: To explore the correlation between gingipain K (Kgp) and inflammatory reaction of gum in the process of orthodontic treatment, and analyse the role of Kgp in the development of gingivitis during orthodontic treatment. METHODS: Totally 45 orthodontic healthy teenagers were randomly chosen for the study. The subgingival plaques were collected simultaneously before orthodontic treatment and 3 months after treatment. 16S rDNA PCR technique was used to detect Porphyromonas gingivalis (P.g) and Kgp. SPSS17.0 software package was used for statistical analysis. RESULTS: The detection rate of Kgp was 35.71% before orthodontic treatment and 67.86% after treatment. Positive correlation (P<0.05) was observed between Kgp and gingival inflammation. CONCLUSIONS: Fixed orthodontic appliances cause plaque accumulation, accordingly slight gingiva inflammation and the increament of P.gingivalis in the early stage.

Key words: Orthodontic treatment, Gingipain K, 16S rDNA PCR technique, Gingivitis

中图分类号:

R783.5

杨刚岭,李伟哲,韩志强,肖水清. 正畸治疗中牙龈蛋白K与牙龈炎性反应的关系[J]. 上海口腔医学, 2015, 24(1): 102-106.

YANG Gang-ling,LI Wei-zhe,HAN Zhi-qiang,XIAO Shui-qing. Detection of gingipain K in the gingival crevicular fluid of orthodontic patients[J]. Shanghai Journal of Stomatology, 2015, 24(1): 102-106.

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