Survivin蛋白在人成釉细胞瘤中的表达及意义

上海口腔医学 ›› 2014, Vol. 23 ›› Issue (4): 481-484.

Survivin蛋白在人成釉细胞瘤中的表达及意义

李乐, 张兴乐, 王鹏, 刘雨

承德医学院附属医院口腔科,河北承德 067000

收稿日期:2014-01-22 出版日期:2014-08-20 发布日期:2014-10-20
通讯作者: 李乐,E-mail:leli_cet6@hotmail.com
作者简介:李乐(1980-), 男, 硕士, 主治医师

Expression of survivin in ameloblastoma and its clinical significance

LI le, ZHANG Xing-le, WANG Peng, LIU Yu

Department of Stomatology, Affiliated Hospital of Chengde Medical College. Chengde 067000, Hebei Province, China

Received:2014-01-22 Online:2014-08-20 Published:2014-10-20

摘要/Abstract

摘要： 目的:探讨survivin在成釉细胞瘤中的表达及意义。方法:采用免疫组织化学S-P法检测70例成釉细胞瘤(ameloblastoma, AB)、 15例恶性AB、30例正常口腔黏膜中survivin的表达。采用SPLUS13.0软件包对数据进行统计学分析。结果:AB、恶性AB中survivin明显表达,恶性AB中阳性表达率最高,为100%,其次为AB(82.9%);正常口腔黏膜轻微表达,其阳性率为30%,各组间差异显著(P<0.05)。结论:AB中survivin高表达,且明显高于正常口腔黏膜。Survivin可能参与AB的发生与发展,AB的侵袭性增加和恶变与survivin的高表达相关。

关键词: 成釉细胞瘤, 恶性成釉细胞瘤, Survivin

Abstract: PURPOSE: To study the expression of survivin in ameloblastoma and its clinical significance. METHODS: Immunohistochemical S-P method was used to detect the expression of survivin in clinical significance. Seventy cases of ameloblastoma (AB), 15 cases of malignant AB and 30 cases of normal oral mucosa were included. SPLUS13.0 software package was used for statistical analysis. RESULTS: Survivin was strongly expressed in AB and malignant AB. The positive rate in malignant AB was up to 100%, followed by 82.9% in AB. Survivin was weakly expressed in normal oral mucosa, with a positive rate of 30%. The difference among the 3 groups was significant (P<0.05). CONCLUSIONS: Survivin is overexpressed in AB compared to normal oral mucosa. Survivin is involved in the development and progress of AB, and the ability of invasion and canceration of AB is correlated with the overexpression of survivin.

Key words: Ameloblastoma, Malignant ameloblastoma, Survivin

中图分类号:

R739.8

李乐, 张兴乐, 王鹏, 刘雨. Survivin蛋白在人成釉细胞瘤中的表达及意义[J]. 上海口腔医学, 2014, 23(4): 481-484.

LI le, ZHANG Xing-le, WANG Peng, LIU Yu. Expression of survivin in ameloblastoma and its clinical significance[J]. Shanghai Journal of Stomatology, 2014, 23(4): 481-484.

参考文献

[1] Ambrosini G, Adida C, Altieri DC, et al. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma [J]. Nat Med, 1997, 3(8): 917-921.
[2] 钟鸣, 张陆莊, 张波, 等. 人成釉细胞瘤中蛋白激酶C-α表达与端粒酶活性的关系[J]. 实用口腔医学杂志, 2006, 22(5): 696-699.
[3] Fine BA, Valente PT, Feinstein GI, et al. VEGF flt-1, and KDR/flk-1 as prognostic indicators in endometrial carcinoma [J]. Gynecol Oncol, 2000, 76(1): 33-39.
[4] Tamm I, Wang Y, Sausville E, et al . IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas(CD95), Bax, caspases, and anticancer drugs [J]. Cancer Res, 1998, 58(23): 5315-5320.
[5] Bria E, Visca P, Novelli F, et al. Nuclear and cytoplasmic cellular distribution of survivin as survival predictor in resected non-small-cell lung cancer [J]. Eur J Surg Oncol, 2008, 34(5): 593-598 .
[6] Spaulding B, Pan D, Ghadersohi A, et al. Characterization of the 12C4 survivin monoclonal antibody and insight into the expression of survivin in human adult tissues [J] . Histopathology, 2006, 49(6): 622-633.
[7] Luo HY, Yu SF, Li TJ. Differential expression of apoptosis-related protein in various cellular components of ameloblastomas [J]. Int J Oral Maxillofac Surg, 2006, 35(8): 750-755.
[8] Kumamoto H, Ooya K. Detection of mitochondria-mediated apoptosis signaling molecules in ameloblastomas [J]. J Oral Pathol Med, 2005, 34(9): 565-572.
[9] Guzman JR , Fukuda S, Pelus LM. Inhibition of caspase-3 by Survivin prevents Weel kinase degradation and promotes cell survival by maintaining phosphorylation of p34Cdc2[J]. Gene Ther Mol Biol, 2009, 13B: 264-273.
[10] Khan S, Aspe JR, Asumen MG, et al. Extracellular, cell-permeable survivin inhibits apoptosis while promoting proliferative and metastatic potential[J]. Br J Cancer,2009,100(7): 1073-1086.